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15 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Mutated proto-oncogenes are asociated with
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Tumor Formation (Gain of Fxn)
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Mutated tumor suppressors are associated with
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release of constraint (Loss of fxn)
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______ leads to over production PDGF that stimulates cells to grow. (H)
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sis
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PDGF = Platelet Derived Growth Factor
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Mutations in these receptor coding genes causes cells to become overly sensitive to growth promoting signals?
Linked to 30% of breast cancers!!(H) |
HER2/neu (erb2 = Epidermal growth factor Receptor B)
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Her 2 new breasts
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Abnormalities in this Signal transducer linked to many cancers
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RAS
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Abnormalities in this Signal transducer linked to Chronic Myelocytic Anemia
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Abl
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Best known Transcription Factor, that Acts on the DNA and controls gene transcription. When overactive it stimulates cells to divide
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myc
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Programmed cell death regulator, when it becomes overly active it prevents cell from dying.
Activated in Lymphoma cells |
Bcl-2
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Tumor suppressor gene linked to problems with apoptosis and many cancers
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p53
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Inherited p53 gene abnormalities?
Dz? What Cancers? |
LFS=(Li-Fraumeni Syndrome)
Soft tissue & Bone sarcomas Brain tumors Breast cancer Adrenal cancer Leukemia |
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Non-inherited p53 gene abnormalities associated with what cancers
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Lung
Colon Breast |
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Retrovirus transcription is sequences in...
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the viral Long Terminal Repeats (LTR)
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A viral oncogene able hybridize with our own DNA
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SRC
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Extra gene in RSV necessary for continued reproduction of the virus
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SRC
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Difference between transforming and non-transforming Retroviruses
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Transforming have Oncogenes (SRC)
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