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12 Cards in this Set
- Front
- Back
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Where do B-cells & T-cells mature?
Main circulating form of lymphocytes: Primary producers of circulating Ab's: Fusion of macrophages is called: |
B- bone marrow, T- thymus
small lymphocytes plasma cells mulinucleated giant cells |
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Forms net-like stroma in hematopoietic, lymphoid, adipose tissues:
Expression of which MHC class is unique to APC's? What type of tissue is deep to epithelium , and prominent in connective tissue? unencapsulated mass of lymphocytes, mostly B-cells: Nodules containing primarily small lymphocytes, no germinal centers: |
reticular cells
MHC Class II diffuse lymphoid tissue lymph node primary lymph nodule |
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Nodule activated by antigen exposure, germinal centers, cap/mantle zone:
cluster of lymphoid nodules in ileum: What are the 3 types of non-encapsulated lymphoid aggregates? What type of epithelium is in Peyer's patches? |
secondary lymph nodule
GALT - Peyer's patches Tonsils (3 types), Peyer's patches, vermiform appendix Simple columnar epithelium |
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Difference between Peyer's patches and vermiform appendix on histology?
tonsil with pseudostratified columnar epithelium, no crypts, no goblet cells: Hypertrophied pharyngeal tonsil from infections is called: |
Peyer's patches - +villi/plicae
tonsil - pharyngeal adenoid |
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tonsil with stratified squamous epithelium, 10-15 crypts, thick capsule:
tonsil with stratified squamous epithelium, 1 crypt, no real capsule: |
Palatine tonsil
Lingual tonsil |
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Makes only T-lymphocytes, most anterior structure in mediastinum:
Appearance on slide? |
thymus
lobules - dark-staining cortex, light-staining medulla (Hassall's corpuscles), no lymphoid nodules, germinal centers |
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What happens in the cortex of the thymus?
What prevents most circulating Ag's from reaching immature T-cells? Concentric layers of flattened epithelial reticular cells in the thymus: |
T-lymphocyte maturation, blood-thymus barrier
blood-thymus barrier Hassall's corpuscles (ice cream?) |
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Two major functions of the spleen?
Appearance on histology? |
defense against microorganisms trying to infect; old RBC destruction
dense CT capsule, no definitive cortex/medulla, white pulp (WBC's), red pulp (RBC's) |
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Two major parts of the white pulp?
Two major parts of the red pulp? |
lymphoid tissue surrounding central arteries - periarterial lymphatic sheaths (PALS) and peripheral white pulp (PWP)
Red pulp (Billroth's) cords, splenic sinusoids |
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Antigens tend to accumulate where in the spleen?
Explain blood flow in the spleen. |
Marginal zone
splenic --> trabecular --> central arteries --> radial branches, penicillar arteries |
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Function of the LVS?
Histological appearance of lymph nodes? Makeup of a lymph node cortex? |
collects fluid in interstitium and returns to blood, contributes imune cells by passing through lymph nodes
+capsule, no red/white pulp, no lobules lots of B-lymphocytes, mostly secondary |
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Region between cortical lymphoid nodules and medulla, mainly T-lymphocytes, lots of high-endothelial venules (HEV's):
Plasma cells usually remain where? How can you tell lymphatic vessels from veins? |
paracortical zone
medullary cords of lymph nodes absence of RBC's, cells |
