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73 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Epidermis derived from...
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ectoderm
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5 Strata of the Epidermis (inside-->out)
(H) |
Basale
Spinosum Granulosum Lucidum Corneum |
Battle Star Galactica Left Caprica
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Mitotically active strata in the epidermis
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Malpighian layer=
Basal + Spinosum |
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Bind S. Basal to basal lamina
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Hemidesmosomes
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Binds adjacent keratinocytes
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Desmosomes (macula adherens)
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Binds to laminin & collagen IV in Basal Lamina
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Integrins
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Give S. Spinosum its spiny appearance
(prickle-cell layer) |
Tonofibrils (tonofilament bundles) made of keratin
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S. Spinosum makes what two types of granules
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keratohyalin &
Lamellar Granules |
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Last layer with nuclei present
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Stratum Granulosum
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Pathology correlate:
See desmosome or hemidesmosome think... |
Squamous Cell carcinoma
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Mutated_________ causes alligator skin (1/250 people have it)
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Keratohyalin
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Produced in the S. Granulosum layer to help cells stick together (H)
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Cholesteryl Sulfate
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Glue
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Keratohyalin granules are rich in which two A.A.'s
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Cystine & Histidine
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Where is S. Lucidum found
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Only in thick skin (eg. palms and soles)
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Contents of S. Lucidum
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No Organells or Nucleus
Only densely packed keratin and eleidin (transformed keratohyalin) |
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Keratinocytes produces what two granule types
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Keratin & Lamellar Granules
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Final location of melanin
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Keratinocytes
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ID
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Keratinocytes
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Enzyme in melanocytes that is UV sensitive
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Tyrosinase
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Melanocytes are derived from what embryological cells
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Neural Crest cells
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reddish yellow melanin
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pheomelanin
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brown melanin
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eumelanin
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What layer of the epidermis are the melanocytes found?
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S. Basale
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Skin color a result of...
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Number of melanin granules in keratocytes
(Not due to number of melanocyte number per unit area) |
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Where do you find Langerhan cells
What is its fxn |
S. Spinosum
Dendritic cell--APC |
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Langerhan cells contain what type of granules
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Birbeck's granules
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ID
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Langerhan cells
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ID
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Langerhan cell
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Where are merkel cells found?
What are they derived from? |
in S. Basale
(more numerous in thick skin) Neural crest |
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Upward projections of the dermis
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Dermal Ridges
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Downward projections of the epidermis
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Epidermal ridges
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Dermis is derived from
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Mesoderm
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Specific a.a.'s for elastic fibers
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Desmosine
Isodesmosine |
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Where are pacinian corpuscles found?
Fxn? |
Dermis: Reticular Layer
Deep Touch |
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Where are Meisener's corpuscles found?
Fxn? |
Dermis: Papillary Layer
Light Touch |
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Dx feature of hypodermis
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Adipose tissue
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Hypodermis is loose CT derived from...
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Mesoderm
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When is the internal hair root sheath no longer visible
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Disappears at the level of the sebaceous gland
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Where is the insertion point for the Arrector Pili m.
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Insert into CT sheath
below sebaceous gland at oblique angle |
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ID
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Sebaceous Gland
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Boobs/Eye balls
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ID
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Eccrine Sweat Glands
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ID
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Apocrine Sweat Glands
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Mechanoreceptor found along collagen lines in the deep dermis and hypodermis
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Ruffini endings
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Meissner's corpuscle
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Pacinian Corpuscle
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Thick or thin
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Thin Skin
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Thick or thin skin
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Thick
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What are some ways to histologically identify the two types of skin?
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S.Lucidum,
presence of hair, glands, a. pili. muscles |
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What are the two parts of skin?
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Epidermis and dermis
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What type of epithelium makes up the superficial layer of skin?
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Keratinized stratified squamous epithelium
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What are the two parts of the deep layer of skin?
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Papillary and reticular
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Where are Meissner’s corpuscles found?
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Dermal-epidermal junction
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Which sensory structure looks like the cut surface of an onion?
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Pacinian corpuscle
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What is the diagnostic feature for the hypodermis?
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adipose
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Which epidermal strata are mitotically active?
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Malpighian layer (s.basale & S.spinosum)
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Which two type of granules are found in keratinocytes of the S. Granulosum?
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Keratin & lamellar
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What concept described protection of the dividing keratinocytes from UV
radiation? |
Melanin pigmentation
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Production of melanin is dependent on what key enzyme?
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tyrosinase
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Which bone marrow-derived cell is found mainly in the S. Spinosum?
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Langerhans’ cells
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Which cell may be a sensory mechanoreceptors and/or a member of the DNES?
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Merkel cells
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Contraction of which structure helps expel sweat from sudoriferous glands?
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Myoepithelial cells
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Which sweat gland releases its product via merocrine section?
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Eccrine & apocrine
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What are the diagnostic features for the secretory and duct portions of sweat glands?
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Duct= s. or str. Cuboidal and darker;
secretory= paler, nuclei basally located and presence of lumen |
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In the box?
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Arrector Pili m.
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Pacinian corpuscle
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Arrow
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S. Corneum
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Gland Type
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Eccrine sweat gland
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in the box
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Meissner's Corpuscle
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Layer @ Arrow
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S. Basal
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Layer
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S. Spinosum
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Layer
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S. Granulosum
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Layer
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S. Corneum
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Gland Type
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Apocrine Sweat Gland
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