Sbl - Antifungals

Front 1

Antifungals with cell membrane inhibition:

Cell wall synthesis inhibition:

Differences between Ampho B and the lipid formulations?

Difference in doses of Ampho B and lipids?

Back 1

Ampho B, -Azoles

echinocandins

Ampho cheaper, but lipid formulations safer

Ampho 0.5-1.5 mg/kg, lipids 3-6 mg/kg

Front 2

Amphotericin B:
#1 SE? What other major SE's? What can you give beforehand to limit the SE's?

When giving an IV bolus, what should you add to prevent digitalis toxicity?

Back 2

#1 SE: kidney toxicity; also anaphylaxis (steroids), chills/fever (APAP, ibuprofen), rigors (meperidine), anemia (EPO)

K+

Front 3

Which drug has hepatotoxicity, and affects CYP3A4?

Used for Cryptococcus CNS infections, DI's with phenytoin and warfarin:

Pregnancy category D, inhibits ergotsterols, CYP450 interactions:

Back 3

Ketoconazole

Fluconazole

Variconazole

Front 4

Used for Mucormycosis in immunocompromised patients:

Two echinocandin drugs?

What drug is PO, often added to Ampho B, and is an anti-metabolite?

Back 4

Posaconazole

caspofungin, micafungin

Flucytosine

Front 5

DOC for:
Aspergillosis:
Blastomycosis:
Oropharyngeal Candidiasis:
Candidemia:
Cryptococcus:
Histoplasmosis:
Mucormycosis:

Back 5

Aspergillosis: Ampho B/Vari, then Itra/Caspo PO
Blastomycosis: Ampho B/Itra, then Fluc PO
Oropharyngeal: Fluc, Ampho B, or Caspo
Candidemia: Fluc, Ampho B, Caspo IV
Cryptococcus: Ampho B + Flucytosine, then Fluc PO
Histo: Itra, if disseminated then Ampho B; then Fluc PO
Mucor: Amp B IV, then Posa