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13 Cards in this Set
- Front
- Back
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What are the risk factors for sarcomas? |
1. Neurofibromatosis 2. Li-Fraumeni 3. Gardener's syndrome 4. Retinoblastoma |
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What is grade of sarcoma based on? |
1. Mitotic activity 2. Degree of differentiation 3. Histologic aggression |
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How do sarcomas spread? |
1. Local extension and invasion 2. Hematogenous mets to lung and liver 3. Seldom crosses fascial planes 4. Seldom violates bone |
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What are the adverse prognostic factors for sarcomas***? |
1. High grade 2. Size>5 cm 3. Age>50 4. Non-extremity location |
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How do you dx a sarcoma? |
1. MRI of mass 2. Plain films 3. Bx |
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Where do sarcomas most often present? |
1. Thigh, groin, buttock 2. Torso |
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How do you tx sarcomas? |
1. Surgery** 2. Adjuvant radiotx 3. Chemo in stage III with G3 or G4 tumors*** |
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When is radiation used in tx of sarcomas? |
1. Pre- and post-operatively 2. High dose |
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What sarcomas are most amenable to chemotx? |
1. Rhabdomyosarcoma |
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What are the ssx of GIST? |
1. Incidental 2. Abdominal pain 3. Abdominal mass 4. GI bleeding |
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What is the antigen associated with GIST? |
1. CD117-- transmembrane tyrosine kinase receptor expressed from c-kit |
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What are the risk factors for aggressive GIST? |
1. Mitotic activity 2. Size <2 or >10 3. Resectability 4. Intestinal origin worse than gastric |
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How do you tx GIST? |
1. Surgery*** 2. Imatinib |
