Sarah-Immunology-Lecture 1

Front 1

define immunology

Back 1

study of protection from foreign macromolecules or invading organisms and our responses to them

Front 2

list 2 benefits of the immune system

Back 2

protection from invaders

elimination of altered self

Front 3

list 2 detriments of the immune system

Back 3

discomfort (inflammation)

damage to self (autoimmunity)

Front 4

list the 3 ways that animals defend themselves against microbial invasions

Back 4

1) physical barriers (skin)
2) innate immunity (inflammation, defensins, macrohpages, lysozyme, neutrophils)
3) specific immunity ( antibody production- B cells, cell mediated immunity-T cells)

Front 5

list the humoral and cellular components of innate immunity

Back 5

humoral
complement
interferon
TNF

cellular
macrophages
neutrophils

Front 6

general characteristics of innate immunity

Back 6

antigen independent
no time lag
not antigen specific
no immunologic memory

Front 7

genera characteristics of acquired immunity

Back 7

antigen dependent
a lag period
antigen specific
development of memory

Front 8

name the cells engaged with innate and acquired immunity

Back 8

innate
macrophages, dendritic cells, neutrophils, NK cells


acquired
T cells, B cells

Front 9

T/F: acquired immunity is evolutionarily ancient

Back 9

F: innate immunity is ancient

Front 10

T/F: acquired immunity is rapid onset

Back 10

F; it takes days to weeks

Front 11

T/F: there are physical barriers assoc. w/ acquired immunity

Back 11

F! no physical barriers

Front 12

name the physical barriers assoc. w/ innate immunity

Back 12

skin
gut villi
lung cilia

Front 13

list the soluble factors assoc. w/ innate and acquired immunity

Back 13

innate
many protein/nonprotein secretions

acquired
immunoglobulins (antibodies)

Front 14

list the cells assoc. w/ innate and acquired immunity

Back 14

innate
phagocytes, NK cells, eosinophils, mast cells

acquired
T and B lymphocytes

Front 15

function of skin( squamous cells) in innate immunity

Back 15

desquamation, flushing, fatty acids

Front 16

T/F: there are physical barriers assoc. w/ acquired immunity

Back 16

F! no physical barriers

Front 17

name the physical barriers assoc. w/ innate immunity

Back 17

skin
gut villi
lung cilia

Front 18

list the soluble factors assoc. w/ innate and acquired immunity

Back 18

innate
many protein/nonprotein secretions

acquired
immunoglobulins (antibodies)

Front 19

list the cells assoc. w/ innate and acquired immunity

Back 19

innate
phagocytes, NK cells, eosinophils, mast cells

acquired
T and B lymphocytes

Front 20

function of skin( squamous cells and sweat ) in innate immunity

Back 20

desquamation, flushing, fatty acids

Front 21

function of GI tract ( columnar cells) in innate immunity

Back 21

peristalsis, low pH, bile salts, fatty acids

Front 22

function of lungs (tracheal cilia) in innate immunity

Back 22

muco-ciliary elevator
surfactants

Front 23

function of nasopharynx and eye (mucus, saliva, tears) in innate immunity

Back 23

flushing
lysozyme

Front 24

function of blood and lymphoid organs (phagocytes and NK cells) in innate immunity

Back 24

phagocytes-phagocytosis and intracellular killing

NK cells-direct and indirect antibody dependent cytolysis

Front 25

function of serum and other serous fluids (lactoferrin/transferrin, intererons/TNF, lysozyme, firbronectin/complement) in innate immunity

Back 25

lactoferrin/transferrin-iron deprivation

interferons/TNF-antiviral proteins, phagocyte activation

lysozyme-peptidoglycan hydrolysis

fibronectin/complement- opsonization, enhanced phagocytosis, inflammation

Front 26

list the serous proteins assoc. w/ innate/nonspecific immunity

Back 26

acute phase proteins
interferons
lysozyme
lactoferrin
cationic proteins

Front 27

which lymphocytes are assoc. w/ humoral responses?

Back 27

B cells

Front 28

which lymphoctyes are assoc. w/ cell-mediated responses?

Back 28

T cells

Front 29

action of B cells in humoral responses

Back 29

B cells have immunoglobulins(recognize antigens), plasma cells make antibodies

Front 30

2 types of T cells and actions

Back 30

1) helper cells ( TH1-help cytotoxic T cells, TH2- help helper B cells)

2) Tc cells ( cytotoxic cells)-kill virus-infected cell and tumor cells

Front 31

T/F: T cells recognize peptides of foreign agents

Back 31

T

Front 32

What molecules bind to MHC 1 and 2?

Back 32

CD8-binds MHC 1

CD4- binds MHC 2

Front 33

immune cells arise from.....

Back 33

stem cells

Front 34

name the 2 types of immune cells

Back 34

myeloid

lymphoid

Front 35

list the derivatives of myeloid cells

Back 35

erythrocytes
platelets
macrophages
neutrophils
eosinophils

Front 36

list the derivatives of lymphoid cells

Back 36

T cells ( CD8, CD4)
B cells (plasma cells, antibodies)

Front 37

derivative of CD8?
derivative of CD4?

Back 37

CD8-CTL

CD4-TH1, TH2

Front 38

function of TH1? function of TH2?

Back 38

TH1- helps cytotoxic T cells

TH2-helps B cells