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11 Cards in this Set
- Front
- Back
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L-DOPA/Carbidopa
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Parkinsons Drugs; DA precursor/AAAD inhibitor to prevent conversion to DA peripherally (carbidopa cannot penetrate BBB)
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Entacapone
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Parkinsons Drugs; COMT inhibitor in the periphery;
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Selegiline
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Parkinsons Drugs; MAO-B inhibitor, prevents breakdown of DA centrally, without affecting NE breakdown peripherally, so no HTN crisis
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Rasagiline
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Parkinsons Drugs; MAO-B inhibitor, prevents breakdown of DA centrally, without affecting NE breakdown peripherally, so no HTN crisis
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Ropinirole
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Parkinsons Drugs; DA agonist; non-ergot amine; used as first line treatment in those <65 years old; or in combination with L-DOPA in advanced PD; anti-oxidant so may be neuroprotective
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Pramipexole
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Parkinsons Drugs; DA agonist; non-ergot amine; used as first line treatment in those <65 years old; or in combination with L-DOPA in advanced PD; anti-oxidant so may be neuroprotective
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Bromocriptine
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Parkinsons Drugs; ergot DA agonist; toxic to heart at doses needed for PD; not used in PD
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Pergolide
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Parkinsons Drugs; ergot DA agonist; toxic to heart at doses needed for PD; not used in PD
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Apomorphine
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Parkinsons Drugs; rescue drug for off periods, given SC, can cause violent emesis, need an antiemetic (trimethobenzamide)
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Rotigotine
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Parkinsons Drugs; DA agonist-transdermal patch; effective in early and late stage PD; binds D3>D2>>D1; treats RLS; helpful for the non-motor PD deficits (cognition and pain) as well; big effing deal (no sarcasm)
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Amantadine
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Parkinsons Drugs; NMDA receptor antagonist, increases DA release and blocks uptake; used as monotherapy or in combination with L-DOPA to prevent motor fluctuations and dyskinesias (also an antiviral for influenza)
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