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15 Cards in this Set
- Front
- Back
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Hereditary spherocytosis will show what Lab results:
-Hb? -PBS? BM? Others? |
Hb is Low
PBS shows spherocytes BM hyperplasia WILL HAVE A NEGATIVE COOMBS TEST!! this is important so you can distinguish b/c this and auto-immune hemolytic anemia |
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How do you diagnose hereditary spherocytosis?
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Osmotic fragility test
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What two crisis can you experience with Hereditary spherocytosis?
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Hemolytic crisis or Aplastic crisis (usually incurred by parvo B19)
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Three crisis Sickle cell patients can experience?
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1.) Vaso-occlusive crisis
2.) Aplastic crisis (parvo) 3.) Sequestration crisis |
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What will you see in the lab values of someone will sickle cell anemia?
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Hb Low
High reticulocytes!= hemolytic sickle cells Howel Jolly bodies--> b/c the spleen sucks |
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This is a hemolytic anemia which causes a decrease in GPI proteins?
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Paroxymal Nocturnal Hemoglobinuria
These patients don't have CD59 and cannot defend themselves from complement activation |
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What is the gene affected in PNH?
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PIG-A
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G6DP can be induced by a medication_________.
What is the pathogenesis behind this disease? |
Primaquine (anti-malarial)
No G6PD means no glutathione which means oxidative damage. Peroxides oxidize Hb and cause Heinz bodies which produce "bite cells" as they pass through the spleen. |
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What can cause hemolytic anemia due to mechanical trauma?
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cardiac valve prosthesis, marrowing aortic stenosis; turbulent flow: Platelet thrombi like in HUS and TTP, also fibrin thrombi like in DIC and Long distance running!!!
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What Lab values would you see with immune hemolytic anemias?
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-Spherocytosis
with a POSITIVE COOMBS test!! |
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Cold agglutinin type think...
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IgM=Mycoplasma or mononucleosis
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If you have anemia due to blood loss, how long would it take reticulocytes to appear?
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Appear after 5-7 days
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Which anemia causes pancytopenia, suppression of stem cells and hypoplasia of BM, and can be caused by Benzene?
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Aplastic anemia
No splenomegaly associated! |
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BM aspirate and BM biopsy of a patient with aplastic anemia would show...
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Aspirate= Dry tap
Biopsy= marked hypocellularity (no blue dots) w/ fat cells |
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Myelophthisic anemia
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Space occupying lesion in BM (usually cancer or myelofibrosis) that causes tear drop cells
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