• Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off
Reading...
Front

Card Range To Study

through

image

Play button

image

Play button

image

Progress

1/29

Click to flip

Use LEFT and RIGHT arrow keys to navigate between flashcards;

Use UP and DOWN arrow keys to flip the card;

H to show hint;

A reads text to speech;

29 Cards in this Set

  • Front
  • Back
Regarding T cells, what is the membrane complex that partners with the TCR?
CD3 complex
Partners with the T cell receptor to send intracellular signals.
What marker can we use to find T cells?
CD3
T cell receptors can recognize ...
ONLY can recognize peptides
These are CD8 T cells that recognize peptides presented by MHC class 1.
Cytotoxic T cells (Tc)

These cells recognize MHC1 and kills infected cells.
These are CD4 T cells that recognize complexes of peptides bound to MCH class2 molecules.
T helper cells (Th)
What is the role of CD4 (T helper) cells?
to recognize MHC2 molecules and secrete cytokines to direct other cells.
Describe the structure of a TCR.
There are actually two types:
alpha:beta
gamma:delta

The majority are alpha:beta, each subunit has a transmembrane protein.
What is the order of T cell development?
Progenitor cells (enter into the thymus)>Pre T cell (B/g rearrangement)>Double negative>Double positive>Selection of either CD4 or CD8>Mature T cells

Mature T cells exit into circulation and traffic to secondary lymphoid tissue.
What stage of T cell migrates from bone marrow to the thymus?
Progenitor cells
What CD marker is present which indicates the a progenitor cell has commited to the T cell lineage?
CD2
During T cell development, gamma and beta competes to express the TCR. If the B chain wins it will then...
B chain will pair with a PRE t-alpha chain and go to the surface to be tested. Then the REAL alpha chain is put on.
Without Rag 1 and Rag 2...
You can have NO B or T cells.
Explain the Goldilocks model of T cell development.
A T cell that bind to self MHC too good or not at all will be eliminated. Those T cells that bind JUST right will undergo positive selection
This T cell subset can recognize antigen without MHC and can recognize peptide and non-peptide antigens?
gamma:delta T cells
There is another subset of T cells call regulatory T cells. We don't know much about them but what is known is that their function invovles...
Tregs suppress the response of self-reactive CD4 T cells and without these you will have an autoimmune disease.
When a mature T cell exits the thymus it will become activated where?
in secondary lymphoid organ (lymph node).
Recognition of antigen by T cells in the secondary lymphoid organ triggers...
activation, proliferation and differentiation
T cell activation requires 2 signals: what are they?
Signal 1: TCR:MHC
Signal 2: CD28: CD80(B7)
The function of IL -2 and how it is related to T cell activation?
An activated T cell releases IL-2 which auto-activates itself and causes further cell division and differentiation.
Describe the differences Th1 and Th2 cells.
Th1= Cell mediated and helps with macrophage activation

Th2= humoral response and assists with B -cells
Cytotoxic T cell effector molecules are..
Perforin, granzymes and Fas ligand
Th1 cell effector molecules that activate macrophages are:
IFN-gamma and IL-2

-more FasL and CD40L
Th2 cells effector molecules that activate B cells are:
IL-4, IL-5, IL-13 and more FasL and CD40 Ligand
Starting with an activated Naive T cell, explain the differentiation into Th1, Th2.
IL-12-->Th1
IL-4-->Th2
Know this flowchart
Flip to other side
How are NK cells related to lymphocytes?
They share the same progenitor (lymphoid) but has no specific receptors.
NK cells are part of the Innate immune response because they cause death by
They destroy targets by releasing perforin and other molecules that damage the tarket cell.
NK cells contain ________ that kill infectected cells?
lytic granules
What receptors activate NK cells?
Fc receptors activate NK cells to destroy antibody coated targets