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29 Cards in this Set
- Front
- Back
Regarding T cells, what is the membrane complex that partners with the TCR?
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CD3 complex
Partners with the T cell receptor to send intracellular signals. |
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What marker can we use to find T cells?
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CD3
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T cell receptors can recognize ...
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ONLY can recognize peptides
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These are CD8 T cells that recognize peptides presented by MHC class 1.
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Cytotoxic T cells (Tc)
These cells recognize MHC1 and kills infected cells. |
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These are CD4 T cells that recognize complexes of peptides bound to MCH class2 molecules.
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T helper cells (Th)
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What is the role of CD4 (T helper) cells?
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to recognize MHC2 molecules and secrete cytokines to direct other cells.
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Describe the structure of a TCR.
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There are actually two types:
alpha:beta gamma:delta The majority are alpha:beta, each subunit has a transmembrane protein. |
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What is the order of T cell development?
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Progenitor cells (enter into the thymus)>Pre T cell (B/g rearrangement)>Double negative>Double positive>Selection of either CD4 or CD8>Mature T cells
Mature T cells exit into circulation and traffic to secondary lymphoid tissue. |
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What stage of T cell migrates from bone marrow to the thymus?
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Progenitor cells
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What CD marker is present which indicates the a progenitor cell has commited to the T cell lineage?
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CD2
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During T cell development, gamma and beta competes to express the TCR. If the B chain wins it will then...
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B chain will pair with a PRE t-alpha chain and go to the surface to be tested. Then the REAL alpha chain is put on.
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Without Rag 1 and Rag 2...
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You can have NO B or T cells.
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Explain the Goldilocks model of T cell development.
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A T cell that bind to self MHC too good or not at all will be eliminated. Those T cells that bind JUST right will undergo positive selection
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This T cell subset can recognize antigen without MHC and can recognize peptide and non-peptide antigens?
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gamma:delta T cells
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There is another subset of T cells call regulatory T cells. We don't know much about them but what is known is that their function invovles...
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Tregs suppress the response of self-reactive CD4 T cells and without these you will have an autoimmune disease.
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When a mature T cell exits the thymus it will become activated where?
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in secondary lymphoid organ (lymph node).
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Recognition of antigen by T cells in the secondary lymphoid organ triggers...
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activation, proliferation and differentiation
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T cell activation requires 2 signals: what are they?
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Signal 1: TCR:MHC
Signal 2: CD28: CD80(B7) |
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The function of IL -2 and how it is related to T cell activation?
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An activated T cell releases IL-2 which auto-activates itself and causes further cell division and differentiation.
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Describe the differences Th1 and Th2 cells.
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Th1= Cell mediated and helps with macrophage activation
Th2= humoral response and assists with B -cells |
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Cytotoxic T cell effector molecules are..
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Perforin, granzymes and Fas ligand
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Th1 cell effector molecules that activate macrophages are:
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IFN-gamma and IL-2
-more FasL and CD40L |
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Th2 cells effector molecules that activate B cells are:
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IL-4, IL-5, IL-13 and more FasL and CD40 Ligand
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Starting with an activated Naive T cell, explain the differentiation into Th1, Th2.
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IL-12-->Th1
IL-4-->Th2 |
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Know this flowchart
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Flip to other side
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How are NK cells related to lymphocytes?
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They share the same progenitor (lymphoid) but has no specific receptors.
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NK cells are part of the Innate immune response because they cause death by
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They destroy targets by releasing perforin and other molecules that damage the tarket cell.
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NK cells contain ________ that kill infectected cells?
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lytic granules
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What receptors activate NK cells?
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Fc receptors activate NK cells to destroy antibody coated targets
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