S-1 Drugs

Front 1

Stimulates erythroid production and differentiation. Stimulates release of reticulocytes from the marrow

Back 1

Erythropoietin

Front 2

Thrombopoietin peptide mimetic binds to TPOR --> JAK/STAT activation --> increased platelet counts

Back 2

Romiplostim (Nplate) Thrombopoietin receptor agonists

Front 3

Promotes proliferation of megakaryocte progenitors & maturation of megakaryocytes --> increased platelet and neutrophil production

Back 3

IL-11 (Oprelvekin)

Front 4

Recombinant G-CSF binds to G-CSFR --> JAK/STAT activation --> production, maturation and activation of PMNs

Back 4

Filgrastim (Neupogen)

Front 5

Recombinant GM-CSF binding GM-CSFR --> JAK/STAT activation --> proliferation and differentiation of PMNs, eosinophils, monocytes & macrophages

Back 5

Sargramostim (Leukine)

Front 6

Binds to ATIII and accelerates inhibition of factor Xa, factor IIa (thrombin), and factor IXa

Back 6

Heparin (Unfractionated, UFH)

Front 7

Binds to ATIII and accelerates inhibition of factor Xa, minor inhibition of factor IIa (thrombin),but NOT factor IXa

Back 7

Enoxaparin (Lovenox) (Low Molecular Weight Heparin, LMWH)

Front 8

Highly basic protein that is used to terminate the action of heparin and LMWH

Back 8

Protamine Sulfate

Front 9

(Selective Factor Xa Inhibitor) Synthetic pentasacchride that promotes AT-III mediated inhibition of factor Xa

Back 9

Fondaparinux (Arixtra)

Front 10

Directly inhibit thrombin (Factor IIa) & prevents conversion of fibrinogen to fibrin

Back 10

Lepirudin (Refludan)

Front 11

Vitamin K antagonist which blocks synthesis of factors II, VII, IX, and X

Back 11

Warfarin (Coumadin)

Front 12

Promotes conversion of plasminogen to plasmin therby stimulating clot lysis

Back 12

Alteplase (Activase)

Front 13

Blocks conversion of plasminogen to plasmin, reverses fibrinolysis and attenuates bleeding

Back 13

Aminocaproic acid

Front 14

Inhibits DHFR --> inhibition of DNA synthesis

Back 14

Methotrexate
(Folate Antagonist)

Front 15

Inhibits Purine Synthesis and purine recycling --> inhibition of DNA synthesis. Incorporated into DNA as a fradulent nucleotide --> chain termination

Back 15

Mercaptopurine
(Purine Antagonists )

Front 16

Inhibits DNA Polymerase -->Inhibition of DNA replication, Incorporated into DNA as a fradulent nucleotide causing chain termination

Back 16

Cytarabine
(Pyrimidine Antagonists)

Front 17

1) Inhibition of thymidylate synthase leading to decreased production of dTMP 2)Incorporation into DNA and RNA leading to strand breaks

Back 17

5-FU (5- Fluorouracil)
(Pyrimidine Antagonists)

Front 18

Once activated, forms covalent bonds between adjacent guanine residues, Cross links DNA --> Inhibition of DNA replication and transcription

Back 18

Cyclophosphamide
(Nitrogen Mustards)

Front 19

Alkylates DNA -->Crosslinking DNA --> Inhibition of DNA replication and transcription

Back 19

Carmustine
(Nitrosourea Drugs)

Front 20

Cross links DNA between adjacent guanine residues --> Inhibition of DNA replication and transcription

Back 20

Cisplatin
(Platinum Compounds)

Front 21

1)Non-specificially Intercalates DNA --> DNA strand breaks, inhibits DNA replication and transcription
2)Inhibits Topoisomerase II --> DS breaks 3)Promotes free radical formation --> Strand breaks

Back 21

Doxorubicin

Front 22

Binds to tubulin --> Blocks polymerization of tubulin --> mitotic arrest --> cell death

Back 22

Vincristine

Front 23

Binds to tubulin & Blocks de-polymerization of tubulin --> stabilizes tubules --> mitotic arrest & cell death

Back 23

Paclitaxel

Front 24

Inhibits topoisomerase II --> permanent double strand DNA breaks

Back 24

Etoposide

Front 25

Monoclonal antibody --> binds EGFR Her-2 => growth inhibition of cells expressing the receptor

Back 25

Trastuzumab (Herceptin)

Front 26

Protein TK Inhibitor that inhibits Bcr-Abl TK by binding to the active site of this mutated protein --> decrease in constitutive activity

Back 26

Imatinab (Gleevac)

Front 27

Recombinant, humanized IgG1 monoclonal antibody that binds VEGF and inhibits VEGF/receptor interaction

Back 27

Bevacizumab (Avastin)

Front 28

Small molecule inhibitor of EGFR (HER-1) TK activity which prevents receptor autophosporylation

Back 28

Erlotinib (Tarceva)

Front 29

Promotes differentiation of promyelocytes to PMNs by facilitating the activity of the mutant PML-RARα

Back 29

Retinoic Acid (Vesanoid, aka ATRA)

Front 30

mTOR inhibitors

Back 30

Everolimus

Front 31

RAF inhibitors

Back 31

Sorafenib

Front 32

Estrogen antagonist (ERα) in breast tissue and estrogen agonist (ERβ) in non-breast tissue (uterine, endometrium) Inhibits estrogen signaling

Back 32

Tamoxifen

Front 33

Estrogen antagonist (ERα) and (ERβ)I in all tissues (represses trans-activation of both isoforms); promotes proteolytic degradation of ER but preserves ERβ

Back 33

Fulvestrant (Faslodex)

Front 34

Block the conversion of androgens to estrogens by competing with androstenediones for the active site of aromatase -->Inhibits Aromatase

Back 34

Anastrozole (Arimidex)

Front 35

Gonadotropin-releasing hormone (GNRH) agonist which causes an intial surge in LH and FSH followed by inhibition of gonadotropin release

Back 35

Leuprolide (Lupron)

Front 36

Non-steroidal anti-androgen (Inhibits the AR)

Back 36

Flutamide (Eulexin)

Front 37

Antidote to Alteplase/Thrombolytics

Back 37

Aminocaproic acid

Front 38

Antidote of sorts for Methotrexate (Protects normal cells from too much killing by methotrexate, cancer cells still targeted by MTX) DFHR converts dietary folate into the tetrahydrofolate form required for thymidine and pyrine synthesis

Back 38

Leucovorin

Front 39

Like an antidote for Heparin

Back 39

Protamine Sulfate

Front 40

Side effects for these two drugs lead to Gout

Back 40

Mercaptopurine, Vincristine

Front 41

These anti-neoplastic agents can penetrate the CNS

Back 41

Methotrexate (only intrathecal), Carmustine (readily penetrates),

Front 42

These anti-neoplastic agents have CNS toxicitiy as a side-effect

Back 42

side effects of : 5-FU, Vincristine, paclitaxel,

Front 43

Pulmonary Toxicity

Back 43

Carmustine side effects

Front 44

Dose dependent cardio-tox

Back 44

Doxorubicin side effects

Front 45

Hypertension

Back 45

Bevacizumab side effects

Front 46

Oral, rapid CYP2C8 metabolism

Back 46

Retinoic Acid (Vesanoid, aka ATRA) metabolism

Front 47

Increased risk of diabetes & cadiovascular disease

Back 47

Leuprolide (Lupron) side effects

Front 48

SEVERE persistent vomiting 1 hr. after administration, dose dependent. Nephrotox

Back 48

Cisplatin side effects

Front 49

*Acrolein (toxic) is a metabolite , and prevention of hemorrhagic cystitis

Back 49

Cyclophosphamide side effects --> use Mensa to counteract