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6 Cards in this Set
- Front
- Back
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Rubella replication
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- (+) polarity RNA genome
- non-segmented - replicated in cytoplasm |
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Rubella transmission
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- respiratory secretions
- no animal vector - vaccine produces protective antibodies |
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Clinical rubella
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- seen in unvaccinated children
- fever, generalized uneven rash, often on face - often asymptomatic in adults - occipital lymphadenopathy |
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Rubella infection progression
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- enters nasopharynx and lungs
- spreads to lymph nodes and reticuloendothelial system - carried in blood - crosses placenta |
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Neonatal Rubella
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- fetal growth retardation
- deafness - cataracts/blindness - mental retardation/small brain - Heart defects |
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Rubella vaccine
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- live attenuated virus
- part of MMR - Contraindicated in pregnant and immunocompromised |
