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15 Cards in this Set
- Front
- Back
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When was narcolepsy first described? |
1877
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What was the first treatment for narcolepsy and when was it first used?
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Amphetamines, 1935
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When was the Sleep Onset REM period first established?
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1960
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When was canine narcolepsy first described?
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1973
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When was hypocretin in animals first described?
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1998
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When was hypocretin in humans first described?
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2000
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What is the narcolepsy tetrad?
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-Excessive Daytime Sleepiness (EDS)
-Cataplexy -Sleep paralysis -Hypnagogic Hallucinations |
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What are the four types of narcolepsy as described by the ICSD-2?
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-Narcolepsy with cataplexy
-Narcolepsy without cataplexy -Narcolepsy due to medical condition -Narcolepsy unspecified: -presence or absence of cataplexy -assumptions about cause |
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Between what ages is narcolepsy most predominate?
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15-30 years
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How was the Multiple Sleep Latency Test developed?
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-Grew out of clinical interest in 1970s
-Need for formalized, objective, measure of sleepiness -Developed from a series of sleep deprivation experiments |
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When is hypocretin testing useful for diagnosing narcolepsy?
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-when sleep apnea makes MSLT interpretation difficult
-patient unable to withdraw from medications that affect MSLT -can be used as long as pt as cataplexy |
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What is the diagnostic criteria for narcolepsy?
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-Mean Sleep Latency (MSL) of 8 minutes or less
-2 or more naps contain REM -normal and sufficient nocturnal sleep occurred in preceding PSG |
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What are the number of naps (MSLTs) required to diagnose narcolepsy?
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-4 naps, two sleep onset REM (SOREM)
-5 if only one SOREM |
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How is daytime sleepiness evaluated?
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-any epoch of REM occurring within 15 minutes of sleep onset
-more than 15 secs of REM -number of naps containing REM counted -REM latency (sleep onset to first epoch of REM) |
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What is the Mean Wake Time (MWT) test protocol?
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1) 4, 40 minute trials every 2 hrs starting 1.5-3 hrs after wake
2) Sleep Onset: 1st epoch of any stage 3) No sleep, terminated after 40 minutes 4) Sleep, continued for 3 epochs of 1, one epoch of any other stage |
