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21 Cards in this Set
- Front
- Back
Describe the torch concept
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Old term to describe a set of similar syndromes all cause CNS, skin, and eye problems in baby
Toxoplasmosis Other (varicella zoster, syphilis, GBS, parvo B19, HIV) Rubella Cytomegalovirus Herpes Simplex |
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What are the screens used for Abs in newborn mean?
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IgMs indicate likelihood of infection
- presence of IgG (and absence of IgM) may reflect transfer of maternal antibodies to the baby |
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Define congenital infection
What is perinatal infection? |
Infection while in the uterus
- infection during labor and delivery |
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Perinatal infections cause what manifestations...
How is this transmitted? |
Meningitis, septicemia, pneumonia, preterm labor
- vaginal flora or while baby goes through the canal |
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MCC of neonatal sepsis?
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Strep agalactiae (Group B strep)
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MC in utero (congenital/prepartum( infections
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• CMV
• Erythrovirus (HPV)-B19 • Rubella virus HIV • VZV • HBV • T. pallidum • T. gondii |
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Perinatal (during labor/ intrapartum) MC infections
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Perinatal (during labor/ intrapartum)
• HSV • CMV • HBV • GBS • N. gonorrhoeae • C. trachomatis |
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What are 3 infections during breast feeding?
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CMV, HIV, HTLV-1
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Toxoplasma gondii clinical manifestations
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Diffuse intracranial calcification
Hydrocephalus Chorioretinitis |
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Rubella virus clinical manifestations
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Cardiac defects
Hearing loss Cataracts |
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Clinical manifestations of CMV
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Microcephalus
Periventricular calcification |
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HSV clinical manifestations in baby
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Vesicular lesions
Keratoconjunctivitis |
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Toxoplasma gondii
a. definitive host b. pregnant mother to baby transmission? c. detections? |
a. cat
b. 50% if later in pregnancy 75% if early transmission 10-25% c. serology IgM, PCR |
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Rubella virus
a. family and form? b. classic triad of fetal problems? c. MC dx method? |
CRS- Congenital Rubella Syndrome
a. togavirus, ssRNA b. cataracts, heart defects, deafness - skin rash has classic "blueberry muffin lesions" c. antiviral IgM (ELISA)--> use MMR vaccine |
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CMV
a. family b. MC what? c. early onset symptoms? d. late onset symptoms e. dx? |
a. herpesviridae
b. mcc of congenital infections c. hepatosplenomegaly, microcephaly, petechiae, jaundice d. deafness, seizures, mental retardations e. urine sample from infant, IgM <3wks of age in blood |
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What are the 3 broad catagories of Herpes infection during 1st month of life?
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a. a) Mucocutaneous (45%): Localized skin, eye and mouth involvement – vesicular rash
b) Encephalitis (30%): CNS infection, +/- skin involvement; 50% have seizures c) Disseminated disease (25%): multiple tissues affected; jaundice, fever, rash (• Worst prognosis) |
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Dx of neonatal herpes?
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quickly!
- skin, eye, mouth infections detectble by PCR or viral cultures, encephalitis by PCR of CSF |
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What is the big bacterial Congenital/prepartum infection?
Results with what in baby? Dx? |
Syphillis (t. pallidum)
- fetal death, still-birth or congenital syphillis -dx with mother and infant-- Serology (non-treponemal and treponemal), darkfield or DFA of nasal discharge - screen at first visit and 28th week |
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GBS (aka?) How much does mother have to have?
MCC of what? What else does it cause in the infant |
strep agalactiae
Gram + cocci, B-hemolytic, 11 serotypes- (>105 vaginal cfu/mL) - MCC of neontal sepsis - also causes pneumonia, shock, cellulitis, meningitis, septic arthritis |
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Chlamydia trachomatis... types found in neonatal infections
infection causes? dx? |
neonatal infection usually by B and D-K
- inclusion conjunctivitis of the newborn and pneumonia - culture is gold standard |
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Dx of gonococcal infections...
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gram stain of eye exudates
- culture of sensitivity of exudates (modified thayer-martin medium) |