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21 Cards in this Set

  • Front
  • Back
Describe the torch concept
Old term to describe a set of similar syndromes all cause CNS, skin, and eye problems in baby
Toxoplasmosis
Other (varicella zoster, syphilis, GBS, parvo B19, HIV)
Rubella
Cytomegalovirus
Herpes Simplex
What are the screens used for Abs in newborn mean?
IgMs indicate likelihood of infection
- presence of IgG (and absence of IgM) may reflect transfer of maternal antibodies to the baby
Define congenital infection

What is perinatal infection?
Infection while in the uterus

- infection during labor and delivery
Perinatal infections cause what manifestations...

How is this transmitted?
Meningitis, septicemia, pneumonia, preterm labor

- vaginal flora or while baby goes through the canal
MCC of neonatal sepsis?
Strep agalactiae (Group B strep)
MC in utero (congenital/prepartum( infections
• CMV
• Erythrovirus (HPV)-B19
• Rubella virus
HIV
• VZV
• HBV
• T. pallidum
• T. gondii
Perinatal (during labor/ intrapartum) MC infections
Perinatal (during labor/ intrapartum)
• HSV
• CMV
• HBV
• GBS
• N. gonorrhoeae
• C. trachomatis
What are 3 infections during breast feeding?
CMV, HIV, HTLV-1
Toxoplasma gondii clinical manifestations
Diffuse intracranial calcification
Hydrocephalus
Chorioretinitis
Rubella virus clinical manifestations
Cardiac defects
Hearing loss
Cataracts
Clinical manifestations of CMV
Microcephalus
Periventricular calcification
HSV clinical manifestations in baby
Vesicular lesions
Keratoconjunctivitis
Toxoplasma gondii
a. definitive host
b. pregnant mother to baby transmission?
c. detections?
a. cat
b. 50% if later in pregnancy 75% if early transmission 10-25%
c. serology IgM, PCR
Rubella virus
a. family and form?
b. classic triad of fetal problems?
c. MC dx method?
CRS- Congenital Rubella Syndrome
a. togavirus, ssRNA
b. cataracts, heart defects, deafness
- skin rash has classic "blueberry muffin lesions"
c. antiviral IgM (ELISA)--> use MMR vaccine
CMV
a. family
b. MC what?
c. early onset symptoms?
d. late onset symptoms
e. dx?
a. herpesviridae
b. mcc of congenital infections
c. hepatosplenomegaly, microcephaly, petechiae, jaundice
d. deafness, seizures, mental retardations
e. urine sample from infant, IgM <3wks of age in blood
What are the 3 broad catagories of Herpes infection during 1st month of life?
a. a) Mucocutaneous (45%): Localized skin, eye and mouth involvement – vesicular rash
b) Encephalitis (30%): CNS infection, +/- skin involvement; 50% have seizures
c) Disseminated disease (25%): multiple tissues affected; jaundice, fever, rash (• Worst prognosis)
Dx of neonatal herpes?
quickly!
- skin, eye, mouth infections detectble by PCR or viral cultures, encephalitis by PCR of CSF
What is the big bacterial Congenital/prepartum infection?
Results with what in baby?
Dx?
Syphillis (t. pallidum)

- fetal death, still-birth or congenital syphillis
-dx with mother and infant-- Serology (non-treponemal and treponemal), darkfield or DFA of nasal discharge
- screen at first visit and 28th week
GBS (aka?) How much does mother have to have?
MCC of what?
What else does it cause in the infant
strep agalactiae
Gram + cocci, B-hemolytic, 11 serotypes- (>105 vaginal cfu/mL)

- MCC of neontal sepsis
- also causes pneumonia, shock, cellulitis, meningitis, septic arthritis
Chlamydia trachomatis... types found in neonatal infections

infection causes?
dx?
neonatal infection usually by B and D-K

- inclusion conjunctivitis of the newborn and pneumonia

- culture is gold standard
Dx of gonococcal infections...
gram stain of eye exudates
- culture of sensitivity of exudates (modified thayer-martin medium)