Rogers 1-7-08 Bilirubin

Front 1

Who makes unconjugated bilirubin

Back 1

macrophage

Front 2

conjugated bilirubin AKA

Back 2

bilirubin glucuronide

Front 3

What transports bilirubin to the smooth ER in the hepatocyte

Back 3

ligandin

Front 4

Adhesion MoleculesMajor Families

C________: calcium-dependent CAMs which link homotypic adhesion to cell proliferation (via catenins)

S________: Mediators of initial (weak) heterotypic adhesive events between leukocytes, platelets and activated endothelial cells

I________: Heterodimeric CAMs which link heterophilic cell adhesion with the ECM and intracellular signaling

I___________-like domain CAMs: Mediator of both heterophilic and homophilic cell adhesion

Back 4

Adhesion MoleculesMajor Families

Cadherins: calcium-dependent CAMs which link homotypic adhesion to cell proliferation (via catenins)

Selectins: Mediators of initial (weak) heterotypic adhesive events between leukocytes, platelets and activated endothelial cells

Integrins: Heterodimeric CAMs which link heterophilic cell adhesion with the ECM and intracellular signaling

Immunoglobin-like domain CAMs: Mediator of both heterophilic and homophilic cell adhesion

Front 5

Melanoma (fast growth phase) is associated with a switch from _-cadherin to N-cadherin expression

Back 5

Melanoma (fast growth phase) is associated with a switch from E-cadherin to N-cadherin expression

Front 6

Naxos disease: deletions in the g-catenin gene results in _____ hair, palmoplantar keratoderma and arrhythmogenic ventricular cardiomyopathy

Back 6

Naxos disease: deletions in the g-catenin gene results in wooly hair, palmoplantar keratoderma and arrhythmogenic ventricular cardiomyopathy

Front 7

In colorectal cancer, chromosomal instability (CIN) is the major form of genetic instability
Mutation of the ___ gene is the earliest event yet identified in sporadic colorectal tumorigenesis, and it is estimated that > 85% of colorectal tumors have somatic mutations of the APC gene

Back 7

In colorectal cancer, chromosomal instability (CIN) is the major form of genetic instability
Mutation of the APC gene is the earliest event yet identified in sporadic colorectal tumorigenesis, and it is estimated that > 85% of colorectal tumors have somatic mutations of the APC gene

Front 8

Mutations in APC gene impair _____ cytoskeletal integrity, cell-cell adhesion and cell migration properties of colon cancer cells.

Back 8

Mutations in APC gene impair actin cytoskeletal integrity, cell-cell adhesion and cell migration properties of colon cancer cells.

Front 9

Mutations of the ___ (___________ _________ ____) gene are present in nearly 80% of sporadic colorectal carcinomas, and a similar proportion of adenomas

Back 9

Mutations of the APC (adenomatous polyposis coli) gene are present in nearly 80% of sporadic colorectal carcinomas, and a similar proportion of adenomas

Front 10

high colon cancer risk inheritance with no polyps

Back 10

hereditary nonpolyposis colorectal cancer

Front 11

The most commonly affected genes in hereditary nonpolyposis colorectal cancer are _____ and _____

Back 11

The most commonly affected genes in hereditary nonpolyposis colorectal cancer are hMLH1 and hMSH2

Front 12

hMLH1 and hMSH2 are mismatch ______ genes

Back 12

hMLH1 and hMSH2 are mismatch repair genes

Front 13

Immunoglobulin-like adhesion molecules include a large group of molecules that are generated from a smaller number of genes by alternative RNA splicing
Collectively, the function by both homophilic and heterophilic binding
The best-studied members of this group are the ______ cell adhesion molecules (_-CAMs) which are expressed predominantly in _______ tissue

Back 13

Immunoglobulin-like adhesion molecules include a large group of molecules that are generated from a smaller number of genes by alternative RNA splicing
Collectively, the function by both homophilic and heterophilic binding
The best-studied members of this group are the neural cell adhesion molecules (N-CAMs) which are expressed predominantly in nervous tissue