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45 Cards in this Set
- Front
- Back
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product of c-met onocogene |
HGF receptor
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mitogenic for epithelial cells, fibroblasts, and hepatocyte
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EGF
TGF-alpha |
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involved in vasculogenesis and angiogenesis
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VEGF
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the main receptor for angiogenesis /vasculogensis that is expressed by endothelial cells
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VEFGR-2
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receptor on lymphatic cells for lymphatic growth
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VEGFR-3
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causes migration and proliferation of monocytes, fibroblasts, and plasma smooth muscle cells
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PDGF
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growth factor that binds to extracellular heparan sulfate to form pools of inactive growth factor
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FGF (VEGF too?
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growth factor centrally involved in wound repair, angiogenesis, and tissue development
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FGF
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growth factor produced by macrophages and is an inflammatory cytokine
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TFG-beta
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growth factor that promotes fibrosis by being chemotactic and mitogenic for fibroblasts. also stimulates collagen deposition
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TGF-beta
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Ras binds to ___ which activates _____
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Raf, MAPK (mitogen associated protein kinases)
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the ___ pathway activates a series of kinases including Akt that promote cell survival
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PI3
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type __ collagen is in BM
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IV
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type __ collagen is fibrillar collagen that is strongest
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I
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type ___ collagen is in cartilage
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II
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which enzyme needs vitamin C?
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LYSINE OXIDASE!!
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___ mediate contact inhibition
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cadherins
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___ mediate calcium dependent interactions b/t cells
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cadherins
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how do cadherins link up to the cytoskeleton
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cadherin, beta catenin, alpha catenin, actin
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what forms provisional blood clots during wound healing before fibrin deposition?
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plasma fibronectin
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wgat forms fibrillar aggregates at sites of wound healing
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tissue fibronectin
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most abundant glycoprotein in the BM
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laminin
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secreted adhesion molecule. contribute to tissue remodeling after injury and is an angiogenesis inhibitor
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SPARC
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secreted adhesion molecule. a family of large multifuctional proteins, some of which inhibit angiogenesis
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thrombospondins
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secreted adhesion molecule which regulates calcification and influences leukocyte migration
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osteopontin
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large multimeric proteins involved in cell adhesion and morphogenesis
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tenacin
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which is bigger hyaluronan or proteoglycans?
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hyaluronan
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growth factor associated with collagen synthesis
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TGF beta
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what is granulation tissue
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deposited in a wound around 24 hours after injury. proliferating fibroblasts and endothelial cells in a loose matrix
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where do new blood vessels come from
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proliferation of existing ECs and also recruitment of EC precursors from bone marrow
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what is the process of Angiogensesis?
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NO dilates preexisting vessels
VEGF increases permeability Metalloproteases degrade the BM Plasminogen activator disrupts cell-cell contact ECs proliferate and migrate toward angiogenic stimulus ECs stop proliferating and mature. they remodel into capillary tubes Periendothelial cells (for capillaries pericytes and for arteries vascular smooth muscle) are recruited |
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interacts with Tie2 to recruit periendothelial cells and mediate vessel maturation
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Ang1
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interacts with Tie2 to increase response to VEGF and cause proliferation and migration rather than maturation
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Ang2
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how does TGF beta stabilize new blood vessels
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by promoting RCM production
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how do proteaess that remodel tissue during EC invasion stimulate angiogenesis
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they release matrix bound FGF and VEGF
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how does fibronectin promote fibroblast engrowth?
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it gives fibroblasts a matrix to bind to
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which growth factors influence fibroblast migration and proliferation?
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PDGF,
EGF, FGF, TGF-beta also IL-1 and TNF |
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MMP production is inhibited by ___
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TGF-beta
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____ are membrane bound MMPs that release the extracellular domains of surface proteins like the precursor forms of TNF and TGF alpha
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ADAMs
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activated MMPs are inhibited by ___
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TIMPs
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in wound healing, what do epithelial cells do first: migrate, proliferate, or deposit BM?
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they migrate first, deposit BM, and then finally proliferate
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in wound healing, which cells come into the blood clot first?
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pmn
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does wound contraction occur in primary intention
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no, just in second intention
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tensile strength of a healed wound plateaus at ____ % at ___ months
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70-80
3 |
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why does wound strength continue to increase
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collage switch to type I
larger diameter fibers crosslinking of collage |
