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20 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Rocky Mountain Spotted Fever (Bug)
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Organism: Rickettsia rickettsii [Gram (-) coccobacilli; take gram staining weakly; obligate intracellular pathogens; zoonotic pathogens]
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Rocky Mountain Spotted Fever (Reservoir, Vector, Transmission)
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Reservoir: Wild rodents, domestic animals (dogs)
Vector: Tick (Dermacentor) Transmission: Tick bite |
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Rocky Mountain Spotted Fever (Virulence Factors and Pathogenesis)
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Infect vascular endothelial cells → (1) induced endocytosis (2) lysis of phagosome membrane - phospholipase A (3) replication in host cell cytoplasm (4) lysis of host cell → vascular damage (hemorrhage, edema), LPS - weak endotoxin activity, vasculitis and thrombosis
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Rocky Mountain Spotted Fever (Clinical, Diagnosis, Treatment)
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Clinical Features: Flu-like symptoms, petechial-hemorrhagic rash (first on extremities → spread to entire body); various organs failures. Fever + Rash + Previous tick bite
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Diagnosis: Clinical presentation + Serologic tests (indirect immuno-fluorescence assay, immuno-staining)
Treatment: Doxycycline |
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Rickettsialpox (Bug)
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Organism: Rickettsia akari [Gram (-) coccobacilli; take gram staining weakly; obligate intracellular pathogens; zoonotic pathogens]
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Rickettsialpox (Reservoir, Vector, Transmission)
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Reservoir: Wild rodents
Vector: Mouse Mite Transmission: Mite bite |
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Rickettsialpox (Virulence Factors and Pathogenesis)
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Infect vascular endothelial cells → (1) induced endocytosis (2) lysis of phagosome membrane - phospholipase A (3) replication in host cell cytoplasm (4) lysis of host cell → vascular damage (hemorrhage, edema), LPS - weak endotoxin activity, vasculitis and thrombosis
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Rickettsialpox (Clinical, Diagnosis, Treatment)
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Clinical Features: Eschar at bite site; Dissemination → flu-like symptoms + fever + generalized rash (randomly distributed)
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Diagnosis: Clinical presentation + Serologic tests (indirect immuno-fluorescence assay, immuno-staining)
Treatment: Doxycycline |
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Epidemic typhus --> Brill-Zinsser disease (Bug)
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Organism: Rickettsia prowazekii [Gram (-) coccobacilli; take gram staining weakly; obligate intracellular pathogens; zoonotic pathogens]
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Epidemic typhus --> Brill-Zinsser disease (Reservoir, Vector, Transmission)
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Reservoir: Humans, squirrels
Vector: Human body louse Transmission: Louse bite |
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Epidemic typhus --> Brill-Zinsser disease (Virulence Factors and Pathogenesis)
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Infect vascular endothelial cells → (1) induced endocytosis (2) lysis of phagosome membrane - phospholipase A (3) replication in host cell cytoplasm (4) lysis of host cell → vascular damage (hemorrhage, edema), LPS - weak endotoxin activity, vasculitis and thrombosis
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Epidemic typhus --> Brill-Zinsser disease (Clinical, Diagnosis, Treatment)
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Clinical Features: Flu-like symptoms; maculopapular rash (first on trunk → spread to extremities); myocarditis, CNS dysfunction; Recrudescent typhus = (10-40 yrs later) endogenous secondary infection by R. prowazekii persisting in reticuloendothelial cells
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Diagnosis: Clinical presentation + Serologic tests (indirect immuno-fluorescence assay, immuno-staining)
Treatment: Doxycycline |
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Endemic typhus --> Murine Typhus (Bug)
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Organism: Rickettsia typhi [Gram (-) coccobacilli; take gram staining weakly; obligate intracellular pathogens; zoonotic pathogens]
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Endemic typhus --> Murine Typhus (Reservoir, Vector, Transmission)
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Reservoir: Rats
Vector: Flea Transmission: Flea bite |
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Endemic typhus --> Murine Typhus (Virulence Factors and Pathogenesis)
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Infect vascular endothelial cells → (1) induced endocytosis (2) lysis of phagosome membrane - phospholipase A (3) replication in host cell cytoplasm (4) lysis of host cell → vascular damage (hemorrhage, edema), LPS - weak endotoxin activity, vasculitis and thrombosis
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Endemic typhus --> Murine Typhus (Clinical, Diagnosis, Treatment)
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Clinical Features: Flu-like symptoms, gradual onset, rash on trunk
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Diagnosis: Clinical presentation + Serologic tests (indirect immuno-fluorescence assay, immuno-staining)
Treatment: Doxycycline |
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Scrub Typhus (Bug)
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Organism: Orientia tsutsugamushi [Gram (-) coccobacilli; take gram staining weakly; obligate intracellular pathogens; zoonotic pathogens]
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Scrub Typhus (Reservoir, Vector, Transmission)
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Reservoir: Rodents
Vector: Mite larva (Chigger) Transmission: Chigger bite |
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Scrub Typhus (Virulence Factors and Pathogenesis)
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Infect vascular endothelial cells → (1) induced endocytosis (2) lysis of phagosome membrane - phospholipase A (3) replication in host cell cytoplasm (4) lysis of host cell → vascular damage (hemorrhage, edema), LPS - weak endotoxin activity, vasculitis and thrombosis
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Scrub Typhus (Clinical, Diagnosis, Treatment)
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Clinical Features: Necrotizing eschar at bite site; flu-like symptoms; maculopapular rash (first on trunk → spread to extremities)
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Diagnosis: Clinical presentation + Serologic tests (indirect immuno-fluorescence assay, immuno-staining)
Treatment: Doxycycline |
