Study your flashcards anywhere!

Download the official Cram app for free >

  • Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off
Reading...
Front

How to study your flashcards.

Right/Left arrow keys: Navigate between flashcards.right arrow keyleft arrow key

Up/Down arrow keys: Flip the card between the front and back.down keyup key

H key: Show hint (3rd side).h key

A key: Read text to speech.a key

image

Play button

image

Play button

image

Progress

1/47

Click to flip

47 Cards in this Set

  • Front
  • Back
Name the Large Vessel Vasculitides
Takayasu's arteritis
Giant cell arteritis/polymyalgia rheumatica
Aortitis associated with an underlying inflammatory disease such as spondyloarthropathy, relapsing polychondritis, or retroperitoneal fibrosis
Name the Medium Vessel Vasculitides
Polyarteritis nodosa
Churg-Strauss syndrome
Kawasaki disease
Name the Small Vessel Vasculitides
Wegener's granulomatosis
Henoch-Schönlein purpura
Leukocytoclastic vasculitis
Microscopic polyangiitis
Cryoglobulinemic vasculitis
Primary angiitis of the central nervous system
Vasculitis associated with connective tissue diseases
T/F Pt's with antiphospholipid syndrome have a prolong PTT, therefore they have a tendency to clot
TRUE

They have a lupus antigen
What is the treatment for vasculitides?
Steroids
DMARDS- immunosupressive drugs
How do you diagnose vasculitis?
Angiograms- shows aneurysms
Biopsy
a cutaneus finding with a fishnet-like appearance is suggestive of?
Livedo Reticularis
Name examples of Type I allergic reactions
Angioedema
Urticaria with erythema
which type of hypersensitivity Rxn is antibody(IgG,IgM) mediated?
Type II
which type of hypersensitivity Rxn is cytotoxic, IgG, IgM, or complement mediated?
Type III
which type of hypersensitivity Rxn is a delay reaction T-cell mediated?
Type IV
Which viruses are assoc with Polyarteritis Nodosa
Hep B and C
What other diseases are assoc with vasculitis?
Infective endocarditis
Syphilis-meningial vascular syphilis
Lupus
Antiphospholipid syndrome
MC type of systemic vasculitis?
Giant cell arteritis, AKA Temporal arteritis
Which population is at risk for GCA?
> 50 years
Females
What are the symptoms of GCA?
Headaches
visual disturbance
jaw pain
arthralgias
> ESR
Anemia
Fever
What disease often coexist with GCA?
Polymyalgia rheumatica
Pain and stiffness of the shoulder and hip girdles and proximal extremities suggests?
Polymyalgia rheumatica
How is GCA confirmed?
Biopsy
How is GCA and PMR treated?
GCA-High dose steroids 6-12 mo
PMR-low dose steroids
This disease results in stenosis of the aorta and its main branches, including involvement of the cerebral, brachiocephalic, renal, mesenteric, femoral, and coronary arteries
Takayasu's arteritis
What are the symptoms of Takayasu's arteritis?
Limb pain
Lightheadedness
B symptoms: malaise, fever, arthralgias
How do you diagnose Takayasu's?
Conventional angiography
How do you treat Takayasu's?
Glucocorticoids
Methotrexate
Cyclophosphamide
A medium vessel vasculitis involving segmental necrotizing lesions, often at arterial branch points, leading to stenoses, aneurysms, thromboses, infarction, or hemorrhage
Polyarteritis Nodosa
How do you treat PAN?
glucocorticoids
immunosuppressive agents
antiviral therapy (pts with Hep B&C)
This is a medium and small vessel vasculitis AKA allergic granulomatosis and angiitis
Churg-Strauss syndrome
What are the MC sites affected by Wegener's Granulomatosis?
sinuses
upper airway
lungs
kidneys
IgA deposition in glomerular lesions is characteristic of this disease
Henoch-Sscholein Purpura
A middle-aged person with chronic asthma who develops pulmonary infiltrates, vasculitis, and eosinophilia. What's the likely diagnosis?
CSS
What are the S/Sx of Henoch-Schonlein purpura?
palpable purpura
arthritis
abdominal pain
fever
glomerulonephritis
What is the treatment of HSP?
Usually supportive and NSAIDS
Occasionally steroids and immunosuppressants
What is the "gold standard" for the diagnosis of any vasculitis?
Biopsy
palpable purpura that can be seen in most of the medium and small vessel vasculitides
Leukocytoclastic vasculitis
How do you treat LCV?
Discontinue nonessential medications because many cases are drug induced
A biopsy from a pulmonary nodule shows granulomas with palisading histiocytes and giant cells. What is the diagnosis?
WEGENER'S GRANULOMATOSIS
What lab findings are useful in diagnosing vasculitis
UA- show RBC cast(glomerulonephritis)
ANCA
eosinophilia
elevated acute phase reactants
ANCA is assoc. with which types of vasculitides?
Wegener's Granulomatosis
Microscopic polyangiitis
CSS (allergic granulomatous vasculitis)
What is a side effect of chronic steroid use?
Osteoporosis
Which population is most affected by Kawasaki's disease?
young children
What are the S/Sx of Kawasaki's?
Swollen hands, lips, mouth, conjunctivitis, and coronary aneurysms
What is the treatment for Kawasaki's?
IV gamma globulin
Aspirin
Aortitis with older individuals suggests?
Takayasus's
What is the pathophysiology of Systemic scleroderma?
(1) a metabolic defect in fibroblast metabolism leading to overproduction of collagen and other matrix proteins
(2) vascular injury and obliteration
(3) immune cell activation and autoimmunity
Which type of scleroderma has skin thickening on just the fingers, toes, and the face.
limited scleroderma
Name examples of DMARDs
Gold Salts
Methotrexate
Azathioprine
Sulfasalazine
Hydrochloroquine
What are the side effects of DMARDs?
Bone marrow suppression