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39 Cards in this Set
- Front
- Back
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cigarette smoke: impairs blood flow and limits ______________
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bicarbonate production
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PPI; Irrev. suppress acid secretion for _______________
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18 hours
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H. pylori: resistance to ______ has been reported
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metronidazole
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calcium carbonate : binds _________ and forms chloride and a gas
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gastric acid
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all antacids: bind to HCL forming ____________
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salt and water
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cimetidine with theophyllin: _____________
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tachyarrhythmias
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________: used for nsaids induced ulcers.
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PPI
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metoclopramide: is an antagonist at the dopamine D2 receptors and causes ______.. just like ______
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EPS; haloperidol
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__________: no irritant or bulk forming property, but need bowel tone to be present
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mineral oil
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Loperamine: _______
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otc
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_________: can cause QT prolongation if given with an cyp 450 inhibitor like erythromycin of ketokonazole
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Cisapride
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loss of D neurons in the subs. niagra : results in _____________________-
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reduced activity of the direct pathwayand movement inhibition
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_____________: improves symptoms in parkinsonism (parkinson's?)
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levodopa/carbidopa
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Levodopa over time...: tolerance, need higher dose becasue ________
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more neurons die
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Parkinsons disease in the young: dopamine agonists like _________________ the onset of dyskinesia...
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pramipaxole or ropiniroledelays
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benztropine and____________in parkinsonism: modify striatal cholinergic intrneurons, which regulate the direct and indirect pathway
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TRIHEXYPHENIDYL
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_________: displace dopamine from presynaptic vesicles and cause cns stimulation
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Amphetamines
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amphetamines cause repetitive movements and ________ at high dose: die to excessive dopamin in the striatum
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bruxism
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pt. taking TRANYLCYPROMINE (MAOi) with ecstasy:_________
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seizures!
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antipsychotic drugs inh. D2 causing _______: like shuffling gate
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EPS
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neuroleptic malignant syndrome die to depression of Dopamine via D2: ___________
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HALOPERIDOLE
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_________ is a phenothiazine which acts by blocking D2 receptors in the...: area postrema
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Prochlorperazine
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moa phenothiazines: blockade of D2 receptors in the ______________results in...:altered muscle toneand acute dystonic reaction
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nigrostriatal system
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parkinsonian symptoms are caused in the __________ nigrostriatal pathway via: d2 receptor blockade
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INDIRECT
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mesocortical system--___________symptoms
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negative
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mesolimbic is up so...: cause of _________symptoms
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POSITIVE
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MOA fluoxetine(SSRI): prevents reuptake of ________ by the seratonin transporter into the presynaptic neurons...
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SERATONIN
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use of SSRI: _______ _______ ________
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depression , anxiety and OCD
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dalay in fluoxetine: autoreceptor need weeks to become desensitized to the increased __________ concentrations caused by fluoxetine...
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synaptic seratonin
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fluoxetine and mania: __________
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can cause it
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highest abuse potential: ____________
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lipophillic drug inhalled!!!
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rate lim. enz. in seratonin synthesis: ________________...
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thryptophan hydroxylase
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lithium tox: _____________
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renal insufficiency
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miperidine and MAOi: _________
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hypertensive crisis...
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Miperidine don't give with: ___
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MAOi
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atypical antidepressent that inhibits 5HT2 receptors and alpha2-adrenergic: _________
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MIRTAZAPINE
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antidepressent drug causing anticolinergic symptoms and cardiac toxicity: ___________
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Amitriptyline
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________side effect: hypothyroidism (GOITER, nephrogenic diabetis insipidus
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lithium
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______----qt interval prolongation
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lithium
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