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16 Cards in this Set

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ma
simple
matrix protein. 1st gene in gag. lines the envelope and associates capsid with the envelope.
ca
simple
capsid protein. most abundant. structural gene which protects the core.

in HIV, it is p21, and this antigen can be tested for
nc
simple
nucleocapsid protein. pos charged, associates with viral RNA. forms the core and protects the genome
pr
simple
protease - cleaves the gag polyprotein (maturation)
rt
simple
reverse transcriptase - transcribes the DNA provirus from the (+)ssRNA
in
simple
integrase - encoded by the pol gene. allows the provirus to integrate.
su
surface glycoprotein.

in HIV, it is gp120. binds to the revceptor (HIV=CD4),

then conf. change.
then binds the coreceptor (either CRC5 or CXRC4).
conf change.
now mb is exposed.
tm
simple
transmembrane protein. (HIV=gp41). 2nd conf change in gp120 allows fusion and the virus to enter the cell. TM and SU are synthesized as a precursor (gp160).
rex
HTLV1.

transactivation of viral genes and turns on cellular genes to make cell a better host.

increases the nuclear export of unspliced and single spliced RNA
tax
HTLV1 - transactivation of viral and cellular genes

increases transcription basically
rev
HIV - transactivation of viral genes and turns on cellular genes to make it a better host

revs up the nuclear export of unspliced and single spliced scripts (the meat and potatoes everything except for rev and tat)
tat
HIV - regulates RNA splicing and export

increases the processivity of RNA polymerase 1000x
nef
HIV only. essential for progression to AIDS

think nefarious
vpu
involved in viral release in HIV only

needed for the Virus to PUut out of the cell
vif
enhances viral infectivity (HIV only)

bings to APOBEC and stops it from hypermutating the DNA to make cell not infective

think Very Infective Virus
vpr
in hiv, needed for the PIC to enter the nucleus


good PR will get you into the nucleus