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10 Cards in this Set
- Front
- Back
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What did this study show about reconstituted doxycyline gel
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undiminished antimicrobial activity for a minimum of 8 weeks
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Doxirobe gel consists of
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42.5 mg docycycline hyclate mixed with a biodegradable polymer gel ( 450 mg N-methyl-2-pyrrolidione and poly DL-lactide)
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What is Doxyclycline and how does it work
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semi synthetic derivative of tetracycline
bacteriostatic, inhibits protein synthesis |
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what is doxycycline's spectrum of activity
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broad spectrum
gram-positive and gram-negative including anaerobes and microorganisms associated with periodontal disease |
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How long is recDG ( reconstituted doxycycline) maintained in the periodontal pocket
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28-42 days
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The final concentration of recDG is
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8.5%
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What were the bacteria used for sensitivity testing in this study
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Staphylococcus aureus and enter
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What is Atridox
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a similar product to Doxirobe labeled for use in humans
carrier is a mixture of polyDL-Lactide dissolved in N-ethyl-2-pyrrolidone with a final concentration of 10% doxycyline |
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Antibiotic from atridox is released locally. what concentration is seen in serum
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less than 0.1microgram /ml -insignificant
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what is the MIC90 for most oral pathogens ie prophyromonus gingival is
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1-6 micrograms /ml
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