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40 Cards in this Set
- Front
- Back
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Respiratory Syncytial Virus (RSV)
Characteristics |
pleomorphic
ss -RNA non-segmented G glycoprotein - attachment Fusion glycoprotein - pathologic fxn |
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Respiratory Syncytial Virus (RSV)
Epi |
early spring
global children under 2 |
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Respiratory Syncytial Virus (RSV)
pathophysiology |
ciliated resp. epi
destruction of cilia obstruction of small airways |
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Respiratory Syncytial Virus (RSV)
clinical |
URI, pneumonia
exacerbation of asthma in old |
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Respiratory Syncytial Virus (RSV)
diag. |
ELISA, DFA
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Respiratory Syncytial Virus (RSV)
treatment |
no steroids
ribavirin for very sick |
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Respiratory Syncytial Virus (RSV)
preventative |
RSV vaccine
cohort patients |
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Respiratory Syncytial Virus (RSV)
transmission |
direct contact
airborne transmission rare nosocomial common |
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Influenza
characteristics |
orthomyxo family
pleomorphic, segmented, ssRNA A,B,C, enveloped Hemagglutanin H1-3, binds sialsilic acid Neuraminidase N1-2 |
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Influenza
Drifts Shifts |
drifts: minor changes in surface spikes (H1-2,N1-2) without changing subtype
shifts: major change; change in subtype. Only in A |
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Influenza
Epi |
mid winter
animal host |
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Influenza
Pathophysiology |
resp. tract
necrosis of ciliated epi bacterial superinfection |
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Influenza
clinical |
chills, nonproductive cough, headache, sore throat
fever, rales and weezing |
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Influenza
diagnosis |
presumptive
ELISA |
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Influenza
treatment |
amantadine
ramatadine - A only zauamivir oseltamivir |
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Influenza
prevention |
vaccine
amantadine or ramantadine |
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Parainfluenza
characteristics |
paramyxovirus family
nonsegmented, -ssRNA types 1-4 neuroaminidase, hemagglutinin, fusionn protein No drifts or shifts |
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Parainfluenza
epi |
type 2 less severe
person to person transmission |
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Parainfluenza
clinical |
URI, acute otitis media
Croup in young kids, type 1 |
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Parainfluenza
diagnosis |
presumptive
IF, EIA serologic for outbreak |
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Parainfluenza
treatment |
antibiotic only with superinfection
ribavirin warm air for croup |
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Rhinovirus
characteristic |
picornavirus family
cytopathic effect (CPE) nonenveloped, +ssRNA 100+ serotypes |
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Rhinovirus
epi |
common cold
spring to early fall high in young children person to person aerosol 50% family, 100% daycare |
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Rhinovirus
pathophysiology |
2-3 d incubation
shed up to a month IgA at 1 week |
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Rhinovirus
clinical |
young infants: febrile, URI
child/adult: afebrile, URI sequelae: exacerbate asthma, otitis media |
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Rhinovirus
diagnosis |
presumptive
don't to tissue culture b.c takes too long |
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Rhinovirus
treatment |
symptomatic
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Rhinovirus
prevention |
hygiene, no vaccine
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Coronavirus
characteristics |
+ssRNA
enveloped with spikes 3 antigens strains: 229E, OC43 |
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Coronavirus
epi |
winter peak
person to person - aerosol |
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Coronavirus
clinical |
URT - cold
LRT - pneumonia GI - watery, nonbloody can lead to MS |
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Coronavirus
diagnosis |
presumptive
difficult to isolate |
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Coronavirus
treatment |
symptomatic
interferon |
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Coronavirus
prevention |
hygiene
no vaccine |
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Adenovirus
characteristics |
large, naked, dsDNA
100+ serotypes, 47 humans enteric: types 40 and 41 |
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Adenovirus
epi |
global
year round fecal to oral (40 &41) |
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Adenovirus
pathophysiology |
replication in epi
necrosis of epi aseptic menengitis |
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Adenovirus
GI Disease System Disease |
GI: acute gastroenteritis, hemorrhagic, ocular, CNS
System: meningoencephalitis, cardiac |
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Adenovirus
diagnosis |
ELISA, culture
DNA hybridization |
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Adenovirus
treatment/vaccine |
no vaccine or treatment
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