Respiratory Pharmacology

Front 1

What form is available for long acting beta agonists?

Back 1

DPI

Front 2

Name the 4 long acting beta-2 agonists

Back 2

Salmetrol
Fluticasone/Salmetrol
Formoterol
Budesonide/Formoterol

Front 3

In which patients should you be careful about using anticholinergic respiratory meds?

Back 3

BPH
Glaucoma

Front 4

What are the side effects of anticholinergic inhalers?

Back 4

dry mouth
pharyngeal irritation
urinary retention
increased intraocular press.

Front 5

What agent (besides albuterol) is first line for pt w/persistent asthma?

Back 5

inhaled steroid

Front 6

What does persistant asthma mean?

Back 6

symptoms at least twice per week

Front 7

Which drug must you educate pt to rinse their mouth after using?

Back 7

inhaled steroids (to prevent dysphonia and thrush)

Front 8

Name the inhaled steroids

Back 8

Beclomethasone
Budesonide
Flunisolide
Fluticasone
Triacinolone
Mometatasone

Front 9

Which inhaled steroids are available in inhalers, not DPI?

Back 9

Beclomethasone
Fluticasone

Front 10

Which asthma drugs have no effect on smooth muscle tone in the airway?

Back 10

Cromolyn and Nedocromil

Front 11

Which patients would maybe be okay candidates for cromolyn?

Back 11

exercise induced asthma or allergic asthma (need to use as prevention)

Front 12

Why is cromolyn used so much in children?

Back 12

minimally absorbed --> minimal side effects

Front 13

What asthma drug is the most potent bronchodilator?

Back 13

theophylline

Front 14

What peak plasma levels of theophylline result in seizures and arrhythmias?

Back 14

>40mcg/mL

Front 15

How long do you have to wait to escalate the theophylline dose?

Back 15

3 days

Front 16

What are the three risk factors for decreased theophylline clearance?

Back 16

1. <1 or >60
2. concurrent disease
3. use of 3A4 inhibitors or d/c of 3A4 inducers

Front 17

What are the leukotriene modifiers?

Back 17

Zilueton
Zafirlikast
Montelukast

Front 18

Which leukotriene modifier should not be used?

Back 18

Zilueton

Front 19

Which Leukotriene modifier has fewer CYP interactions and is better tolerated?

Back 19

Montelukast

Front 20

What does Zileuton cause?

Back 20

hepatotoxicity and agranulocytosis

Front 21

What is the Anti-IgE Aby that is given subQ to prevent response to allergens?

Back 21

Omalizumab

Front 22

What is Omalizumab approved for?

Back 22

moderate-severe persistent asthma w/allergic componenent and poor control

Front 23

What must be tested before prescribing Omalizumab?

Back 23

IgE levels

Front 24

Which long acting beta agonist is preferred in pregnancy?

Back 24

salmetrol

Front 25

What drug might you consider for major night component to asthma?

Back 25

theophylline

Front 26

When should pt w/hx of tobacco use have spirometry?

Back 26

age 45

Front 27

Name 3 inhaled short acting beta agonists?

Back 27

Albuterol
Levalbuterol
Pirbuterol

Front 28

Do you need to give more or less beta agonist if using nebulizer?

Back 28

more

Front 29

which beta agonists come in pill form?

Back 29

albuterol
metaproterenol
terbutaline

Front 30

What is the MDI or nebulized anticholinergic called?

Back 30

Atrovent

Front 31

What is ipratropium + albuterol called if it is in nebulized form?

Back 31

Duoneb

Front 32

What is ipratropium+albuterol called if it is MDI?

Back 32

Combivent

Front 33

Which asthma drug is used off label for asthma tx as add-on tx to inhaled steroids?

Back 33

Ipratropium