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9 Cards in this Set
- Front
- Back
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which leukotriene contributes the most to asthma?
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LTD4 (LTA4 and LTE4 also contribute to a lesser degree)
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antagonists to leukotrienes are? (2)
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1. zarfirlukast
2. montelukast |
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what drug is an inhibitor of the enzyme 5-lipoxygenase?
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zileutin
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how do aspirin and ibuprofen increase symptoms of asthma?
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they are cyclooxygenase inhibitors which causes arachidonic acid to enter the lipoxygenase pathway -> leukotriene pathway
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why are atropine and ipratropium bromide effective for treating asthma?
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they are antimuscarinic receptors which cause bronchodilation
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which phosphodiesterase inhibitor is used to treat asthma and what is its mechanism of action?
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increases intracellular cAMP
Theophylline |
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what occurs during the acute stage of asthma?
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bronchoconstriction
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what happens during the late phase of asthma?
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inflammation: airway edema, mucus
production, and ongoing bronchoconstriction |
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what is the most accurate and specific testing modality for asthma?
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Pulmonary function testing (“PFTs”)
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