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82 Cards in this Set
- Front
- Back
What are Clara cells
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noncilliated, columnar w/secretory granules
secrete component of surfactant, degrade toxins, act as reserve cells |
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What are Type 1 cells
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97% of alveolar surfaces (line them), are squamous cells + optimal for gas diffusion
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What is indicative of fetal-lung maturity?
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lecithin:sphingomyelin ratio > 2.0
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Type 2 cells
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cuboidal and clustered,
secrete surfactant, as a precursors to Type 1 cells and other Type 2 cells, proliferate during lung damage |
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What is bronchopulmonary segment
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tertiary (segmental) bronchus and 2 arteries (bronchial and pulmonary)
(Arteries run w/Airways) veins and lymphatics drain along borders |
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What is the relationship of the pulmonary artery to the bronchus at each lung hilus?
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RALS
Right: Anterior Left: superior |
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What lung is a more common site for inhaled foreign body and why?
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Right lung, b/c the R main stem bronchus is wider and more vertical than the left
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What structures perforate the diaphragm at:
T8 T10 T12 |
T8: IVC
T10: esophagus, vagus T12: aorta, thoracic duct, azygous vein (red, white and blue) |
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What muscles used for inspiration and expiration during quiet breathing?
during exercise? |
quiet/Normal: diaphragm (inspiration), passive (expiration)
exercise: Inspiration: external intercostals, Scalene mm, Sternomastoids Expiration: rectus abdominis, internal + external obliques, transversus abdominis, internal intercostals |
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What happens when there is a deficiency in surfactant
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neonatal RDS
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How do you calculate collapsing pressure
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P = 2T/r
T= tension, r=radius |
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What is vital capacity
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TV + IRV+ ERV
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What is functional residual capacity
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RV + ERV
volume in lungs after NL expiration |
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What is inspiratory capacity
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IRV + TV
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How do you calculate physiologic dead space (Vd)?
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Vd = Vt + [(PaCO2 - PeCO2) / PaCO2]
Vt = tidal volume PaCO2 = arterial PCO2 PeCO2 = expired air PCO2 |
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What part of the lung is the largest contributor of functional dead space?
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apex of healthy lungs
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What is physiological dead space
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anatomical dead space of conducting airways plus functional dead space in alveoli (volume of air that doesn't take part in gas exchange)
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When is inward pull of lungs balanced by outward pull of chest wall
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FRC (functional residucal capacity = RV + ERV)
when system pressure is atmospheric pressure |
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What are the 2 forms of adult hemoglobin
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T and R
T (taut) has low affinity for O2 (R shift) R (relaxed) has high affinity for O2 (L shift) |
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What conditions favor Right shift or T form of Hb?
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increases in:
Cl-, [H+]/altitude, CO2, 2,3-BPG, exercise/metabolic needs, temperature lead to increase O2 unloading to tissue |
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How do you treat cyanide poisoning
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use nitrites to oxidize Hb to methemoglobin, which binds cyanide (this allows cytochrome oxidase to resume function),
then use thiosulfate to bind cyanide -> thiocyanate, which is renally excreted |
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How is methemoglobin treated
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methylene blue
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What happens in hemoglobinopathies (methemoglobin, CO poisoning)
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tissue hypoxia from decrease O2 saturation and decrease O2 content
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What is perfusion limited in pulmonary circulation
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O2 (normal conditions), N2O, CO2
gas equilibrates early along capillary length diffusion can be increased only if blood flow increases |
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What is diffusion limited in pulmonary circulation
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O2 (emphysema, fibrosis), CO
gas does NOT equilibrate by the time blood reaches the end of the capillary large partial pressure difference b/w alveolar air and pulmonary capillary blood |
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What is primary pulmonary HTN
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due to an inactivating mutation in BMPR2 gene (normally functions to inhibit vascular smooth m proliferation); poor prognosis
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What are secondary causes of pulmonary HTN
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COPD, mitral stenosis, recurrent thromboemboli, autoimmune dz, L-to-R shunt, sleep apnea or living at high altitude
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What is the course of pulmonary HTN
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severe respiratory distress -> cyanosis and RVH -> death from decompensated cor pulmonale
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What are normal pulmonary artery pressure?
What are the values for pulmonary HTN? |
NL: 10-14 mmHg
HTN: >25 mmHg or > 35 during exercise |
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What happens to O2 levels when Hb decreases?
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O2 content of arterial blood decreases
O2 saturation and arterial PO2 do NOT decrease |
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What is the alveolar gas equation
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PAO2 = 150 - (PACO2/0.8) (approx)
actual: PAO2 = PIO2 - (PACO2/R) |
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What is an A-a gradient
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PAO2 - PaO2 = 10-15 mmHg
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Under what situations is the A-a gradient increased
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hypoxemia (shunting, V/Q mismatch, fibrosis--diffusion block)
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What can cause hypoxemia
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decreased PaO2
high altitude (NL A-a gradient) Hypoventilation (NL A-a gradient) V/Q mismatch (increased A-a gradient) Diffusion limitation (increased gradient) R-to-L shunt (increased gradient) |
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What can cause hypoxia
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decreased O2 delivery to tissues
decreased CO hypoxemia anemia CN poisoning CO poisoning |
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What can cause ischemia
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loss of blood flow
impeded arterial flow reduced venous drainage |
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Describe V/Q at apex and at base
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apex (zone 1): V/Q high ( = 3), wasted ventilation, high alveolar pressure compressed capillaries
PA > Pa > Pv (PA = arterial pressure) base (zone 3): V/Q low (= 0.6), wasted perfusion, Pa > Pv > PA, both ventilation and perfusion are greater at the base of lung than at the apex |
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What happens when V/Q -> 0
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airway obstruction (shunt)
100% O2 does NOT improve PO2 |
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What happens when V/Q -> infinity
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blood flow obstruction (physiologic dead space)
100% O2 does improve PO2 (assuming <100% dead space) |
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What is Haldane effect?
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in lungs, oxygenation of Hb promotes dissociation of H+ from Hb,
this shifts equilibrium towards CO2 formation, releasing CO2 from RBC |
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What is Bohr effect?
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in peripheral tissue, increase H+ from tissue metabolism shifts curve to right, unloading O2
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What is carbaminohemoglobin
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CO2 bound to Hb at N terminus of globin, NOT heme
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What is Virchow's triad
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1. Stasis
2. Hypercoagulability 3. Endothelial damage |
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What is Homan's sign
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DVT sign
dorsiflexion of foot -> tender calf m can prevent w/heparin |
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What is the hallmark sign for COPD
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decreased FEV1/FVC ratio (FEV1 decreases more than FVC)
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Curschmann's spirals
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shed epithelium form mucous plugs w/asthma in COPD
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What is centriacinar emphysema
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caused by smoking
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What is panacinar emphysema
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alpha1-antitrypsin deficiency (also liver cirrhosis)
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paraseptal emphysema
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assoc w/bullae -> can rupture -> spontaneous pneuomthorax
often in young, otherwise healthy males |
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What are the clinical findings in emphysema in COPD
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dyspnea, decreased breath sounds,
tachycardia, late-onset hypoxemia due to eventual loss of capillary beds (w/loss of alveolar walls), early onset dyspnea |
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What are the clinical findings in chronic bronchitis in COPD
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wheezing, crackles, cyanosis (early-onset hypoxemia due to shunting), late-onset dyspnea
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What is bronchiectasis in COPD
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chronic necrotizing infection of bronchi -> permanently dilated airways, purulent sputum, recurrent infections, hemoptysis
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What conditions can cause bronchiectasis
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bronchial obstruction, CF, poor ciliary motility, Kartagener's syndrome
can get aspergillosis |
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What disease states can cause restrictive lung dz
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1. Poor breathing mechanics (extrapulmonary):
poor muscular effort (polio, myasthenia gravis), poor structural apparatus (scoliosis, morbid obesity) 2. Interstitial lung dz: ARDS, neonatal RDS, pneumoconioses, sarcoidosis, idiopathic pulmonary fibrosis, Goodpasture's, Wegener's, Eosinophilic granuloma (Histiocytosis X), Drug toxicity (Bleomycin, busulfan, amiodarone) |
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What is idiopathic pulmonary fibrosis
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repeated cycles of lung injury and wound healing w/increased collagen
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What are the main pneumoconioses
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Coal miner's, silicosis, asbestosis
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Coal miner's pneuomoconioses
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affects upper lobes, can result in cor pulmonale and Caplan's syndrome (combo of RA and pneumoconioses that manifest as intrapulmonary nodules)
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Silicosis
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"eggshell" calcification of hilar lymph nodes, macrophages respond to silica and release fibrogenic factors -> fibrosis
silica might impair macrophages, increasing susceptibility to TB foundries, sandblasting, mines |
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asbestosis
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"ivory-white," calcified pleural plaques
asbestos bodies in macrophages: golden-brown, fusiform rods that look like dumbbells increased incidence of bronchogenic CA and mesothelioma |
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When is surfactant made in fetus
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most abundantly made after 35th week of gestation
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neonatal RDS
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lecithin:sphingomyelin ratio < 1.5
persistently low O2 tension -> risk for PDA, therapeutic supplemental O2 can cause retinopathy of prematurity |
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What are the risk factors for neonatal RDS and do you treat it
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Risk factors: prematurity, maternal diabetes (b/c of high insulin), C-section (decrease release of fetal glucocorticoids)
Trx: maternal steroids BEFORE birth, artificial surfactant for infant, thyroxine |
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Pathogenesis of ARDS
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diffuse alveolar damage -> increased alveolar capillary permeability -> protein-rich leakage into alveoli -> hyaline membrane
initial damage from neutrophilic substances toxic to alveolar wall, activation of coagulation cascade, or O2-derived free radicals |
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What can cause ARDS
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trauma, sepsis, shock, gastric aspiration, uremia, acute pancreatitis, aminotic fluid embolism
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What conditions are sleep apnea associated with?
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obesity, loud snoring, systemic/pulmonary HTN, arrhythmias, and possibly sudden death
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What conditions cause a transudate in a pleural effusion
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CHF, nephrotic syndrome, or hepatic cirrhosis
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What conditions cause an exudate in a pleural effusion
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malignancy, pneumonia, CVD (collagen vascular dz), trauma (occur in states of increased vascular permeability, like ARDS)
must be drained in light of risk of infection |
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Lymphatic pleural effusion
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milky fluid, increased triglycerides
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Lobar pneumonia: characteristics and organisms
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intra-alveolar exudate -> consolidation, can involve entire lung
orgs: Pneumococcus most frequently, Klebsiella |
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Bronchopneumonia: characteristics and organisms
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acute inflammatory infiltrates from bronchioles into adjacent alveoli,
patchy distribution of >1+ lobes orgs: S. aureus, H. flu, Klebsiella, S. pyogenes |
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Interstitial/atypical pneumonia: characteristics and organisms
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diffuse patchy inflammation localized to interstitial areas at alveolar walls, involves >1+ lobes,
more indolent course than bronchopneumonia orgs: Viruses (RSV, adeno), Mycoplasma, Legionella, Chlamydia |
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What is a characteristic finding on X-ray for lung cancer
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pneumonic "coin" lesion
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what does primary lung cancer in lung present with
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cough
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What are the complications that can happen w/lung cancer
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SPHERE:
Superior vena cava syndrome Pancoast's tumor Horner's syndrome Endocrine (paraneoplastic) Recurrent laryngeal Sx (hoarseness) Effusions (pleural or pericardial) |
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What lung cancer type has PTHrp/parathyroid-like activity
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squamous cell CA
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What lung cancer types are found more centrally
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squamous and small cell
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What lung cancer types are found more peripherally
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large cell and adenocarcinoma (bronchial and bronchioalveolar)
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What is the most common lung cancer in women and nonsmokers
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adenocarcinoma
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What histology is seen w/adenocarcinoma
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Clara cells -> Type 2 pneumocytes, multiple densities on CXR
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What is the consequence of bronchioloalveolar adenocarcinoma
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hypertrophic osteoarthropathy
this type of cancer grows along airways and can present like pneumonia |
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What cancer is a neoplasm of neuroendocrine Kulchitsky cells and what are they?
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small dark blue cells
found in small cell CA |
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what is carcinoid syndrome
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flushing, diarrhea, wheezing, salivation and R valvular heart dz
can be from a carcinoid tumor |