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24 Cards in this Set
- Front
- Back
Ventolin: use and action |
binds to beta2- adrenergic receptors in smooth airway muscle; leads to activation of adenylcyclase and > levels of cAMP inhibits phosporylation of myosin& intracellular Ca+ relaxes smooth airway muscles--- bronchodilation |
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Ventolin: side effects and interactionxs |
nervousness, restlessness, tremor, PARADOXICAL BRONCHOSPASM, chest pain, palpitations
other adrenergic agents, MAO inhibitors, beta blockers, < serum digozxin, tricyclic antidepressants, K+ losing diuretics |
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Ventolin: Implications |
lung sounds, BP, pulse before giving& during peak pulmonary function tests & sputum colour paradoxical bronchospasm (wheezing) can cause < in serum K+ |
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Ipatropium: uses and action |
allergy, cold, cough remedies, bronchodilators--- anticholinergic
Inhibits cholinergic receptors in bronchial smooth muscle; < cGMP= local bronchodilation |
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Ipatropium: side effects and interactions |
dizziness, headache, nervousness, blurred vision, sore throat, bronchospasm, cough, hypotension, palpitations, GI irritation, nausea, rash, allergic rx.
other drugs with anticholinergic properties (histamines, etc.) |
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Ipatropium: Implications |
allergies to ipatropin& belladona alkaloids respiratory status when used with other bronchodialtors, give adrenergic bronchodialators first, then ipatropium, then corticosteroids |
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Albuterol: use and action |
bronchodilators--- adrenergics binds to beta 2 adrenergic receptors in airway smooth muscle--- adenyl cyclase--- > levels of cAMP relaxes smooth muscle airways |
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Albuterol: side effects and interactions |
nervousness, restlessness, tremor, PARADOXICAL BRONCHOSPASM, chest pain, palpitations
other adrenergic agents, MAO inhibitors, beta blockers, < serum digoxin, tricyclic antidepressants, K+ losing diuretics, caffeine |
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Albuterol: Implications |
lung sounds, BP, pulse, before & during peak sputum, pulmonary function tests bronchospasm < serum K+ unsual/ bad taste take first before other bronchodilators mouth care |
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Flucticasone (Flovent): use and action |
anti- inflammatory--- corticosteiroid
potent, locally acting anti- inflammatory and immune modifier
< frequency and severity of asthma attacks |
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Flucticasone: side effects and interactions |
headache, ANAPHYLAXIS, LARYNGEAL EDEMA, URTICARIA, BRONCHOSPASM, CHURG- STRUSS SYNDROME CYP3A4 inhibitors |
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Flucticasone: side effects and interactions |
respiratory status& lung sounds, pulmonary function tests < bone mineral density hypersensitivity adrenal function test give bronchodilator first & then corticosteiroid |
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Salmetrol: use and action |
bronchodilator--- adrenergic accumulation of CAMP at beta 2 adrenergic receptors |
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Salmetrol: side effects and interactions |
headache, ASTHMA RELATED DEATH beta blockers, MAO inhibitors &tricyclic antidepresssants, CYPS4A and caffeine > levels and risk of cardio effects |
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Salmetrol: Implications |
lungs sounds, pulse, blood pressure pulmonary function tests paradoxical bronchospasm (wheezing) > serum glucose not used as a monotherapy not used for acute symptoms of asthma |
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Montelukast: use and action |
allergy, cold, cough remedies--- leukotriene antagonists antagonizes the effects of leukotrienes which mediate: airway edema, smooth muscle constriction, altered cellular activity < severity of allergic rhinitis and exercise induced asthma attacks |
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Montelukast: side effects and interactions |
SUICIDAL THOUGHTS, SJS, TOXIC EPIDERMAL NECROLYSIS, EOSINOPHILIC CONDITIONS drugs that induce CYP450 enzyme system may decrease its effect |
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Montekulast: Implications |
respiratory status allergic rx. changes in behaviour rash AST/ALT values take in evening/ at least 2 hrs before exercise be alert for anxiety, agitation, panic attacks/ behavioral changes |
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Prednisone: use and action |
anti- inflammatories (steiroidal) immune modifiers
suppress inflammation& immune response, intense metabolic effects, supress adrenal function at chronic doses of 5mg a day, replaces endogenous cortisol in deficiency states |
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Prednisone: side effects & interactions |
depression, euphoria, hypertension, PEPTIC ULCER, anorexia, nausea, vomitting, acne, < wound healing, ecchymoses, fragility, adrenal suppression, THROMBOEMBOLISM, muscle wasting, osteoporosis, cushingoid appearance
thiazide& loop diuretics, amphotericin B, digoxin, oral contraceptives, phenytoin, NSAIDS, live virus vaccines, fluroquinolones |
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Prednisone: implications |
assess involved systems, signs of adrenal insufficiency fluid status serum electrolytes & glucose, cholesterol, lipid, thyroid give in AM to coincide with cortisol release with food DO NOT STOP SUDDENLY contact physician if abd. pain/ tarry stools occur |
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Moxifloxacin: use and action |
anti- infective--- fluoroquinolones
inhibits bacterial DNA synthesis by inhibiting DNA gyrase enzyme |
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Moxifloxacin: side effects and interactions |
> INTRACRANIAL PRESSURE, TORSADE DE POINTS, PSEUDOMEMBRANOUS COLITIS, SJS, HYPERSENSITIVITY RX. including ANAPHYLAXIS
erythromycin, antipsychotics, tricyclic antidepressants, antineoplastics, cyclosporine, corticosteiroid therapy |
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Moxifloxacin: implications |
signs and symptoms of anaphylaxis (rash, pruritis, laryngeal edema) bowel movements (bloody stool, cramping, diarrhea) rash (SJS) peripheral neuropathy (pain, burning, tingling, etc.) give over 60 mins |