Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
8 Cards in this Set
- Front
- Back
|
Most common manifestation of CF?
|
Pancreatic insufficiency
|
|
|
Most common pathogen found in CF?
|
Pseudomonas
|
|
|
90% of people with CF have this pulmonary function disease?
|
COPD
|
|
|
CFTR gene?
|
7q31-32
|
|
|
What does the mutation do?
|
The chloride ion channel protein is messed up. You get increased intracellular sodium in the lungs and an increase in sodium and chloride in sweat.
|
|
|
What is wrong with the CFTR protein that causes its degredation in a class II mutation?
|
-it is not glycosylated and causes a defect in the protein, undergoes accelerated degredation in the ER
-this is from abnormal trafficking that leads to its degredation before it reaches the membrane |
|
|
Why does it affect males more?
|
it is a obstructive disease of ducts, the vas deferens is a smaller duct
|
|
|
What does the normal CFTR protein have to do with pseudomonas?
|
-it has some sort of magical power to internalize the bug
-it binds the LPS and internalizes it |
