• Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off
Reading...
Front

Card Range To Study

through

image

Play button

image

Play button

image

Progress

1/42

Click to flip

Use LEFT and RIGHT arrow keys to navigate between flashcards;

Use UP and DOWN arrow keys to flip the card;

H to show hint;

A reads text to speech;

42 Cards in this Set

  • Front
  • Back
what would you want to use for B-lactamase producing staphylococci (2)
Nafcillin and oxacillin
person has meningitis, pt is allergic to penicillin, what should you consider for treatment?
3rd/4th gen ceph
pt has renal problems and you want to use a cephalosporin that is able to cross the BBB and is good at treating Gram Negatives..what would you give
ceftriaxone

is cleared through biliary mech
what is the drug of choice for wounds infected with E.coli?
3rd gen Cephs
3rg gen cephalosporins treat what bugs?
PSEUDOMONAS (alt; ceftazidime)
Klebsiella (pneumoniae, ceftazidime – DOC)
E.coli (wounds, DOC)
Proteus
Serratia
if you have a serious Gram neg infection what do you want to use?
3rd generation ceph
Nosocomial infections and bacteremias
Complicated UTIs
Complicated skin /soft tissue infections

use what?
3rd gen Cephalosporin
what is the drug of choice for Gonorrhea and Lyme disease?
ceftriaxone (3rd gen)
if you have an immunocompromised host what type of drug do you want to use
3rd gen
What is the preferred treatment for community acquired pneumonia? Hospitalized and Outpatient

**
Hospital: Ceftriaxone + azithromycin

Outpatient: Azithromycin … or … clarithromycin … or … doxycycline
Even wider spectrum, more resistant to beta-lactamases...this describes?
Cefepime (4th Gen)
Carbapenems (Imipenem).. bactericidal or static?
bactericidal
mech of action for carbapenems?
similar to pens and ceph
Primary use for carbapenems?
Extended spectrum beta-lactamases (aka bugs that are not affected by cephs and pens)

… but … its not usually a 1st choice
pt has a serious nosocomial and mixed infections caused by multidrug resistant aerobic and anaerobic enteric bacilli...what might you use?
carbapenems
G- pneumonia and bacteremia, complicated UTIs, serious infections by Pseudomonas (alt)

can use?
carbapenems
DOC for enterobacter?
**
carbapenems (Imipenem)
DOC for ESBL producing Kleb?

***
Carbapenems (Imipenem)
what is Imipenem always used with? Why
Cilastatin

Imipenem is rapidly broken down by a dehydropeptidase in the proximal renal tubule

cilastatin blocks this breakdown
can carbapenems cross the BBB?
Yeppers
carbapenems are resistant to most lactamases but there are 2 exceptions (this is probably more just FYI, but will be useful in the future)
G- porins may resist entry

hydrolyzed by metallo-B-lactamases
what bug develops resistance rapidly to carbapenems?
Pseudomonas
This drug should NOT be used in patients with seizures, as it can cause them...
carbapenems
what is the "magic bullet" for gram negatives?
Monobactams
mechanism for monobactam?

**
Only binds to a PBP (penicillin binding protein) present in GRAM NEGATIVE bugs
what are some of the bugs that Monobactams can treat
Enterobacter, Serratia, Pseudomonas (alt), Neisseria
do monobactams have cross sensitivity with penicillins? what about carbapenems?
mono: no

carb: yes
Serious G- infections, such as MDR pseudomonoas can be treated with what?
Monobactams
what are the beta lactamase inhibitors?
Clavulanic acid
Sulbactam
Tazobactam
what is the monobactam drug?
Aztreonam
what does the vancomyocin bind to? what does this mean for resistance?
alanine alanine

if there is resistance, this binding site gets altered, thus it doesn't work
vancomycin: bactericidal or static?
Bactericidal … but
NOT a beta lactam!!!
drug for Colitis (C. difficile)
Vancomycin
drug for Enterocolitis (S. aureus)
Vancomycin
drug of choice for MRSA?

**
Vancomycin
DOC for enterococci?
Vancomycin
Alt choice for pseudomembranous colitis...? DOC?
alt: vanco

DOC: Metronidazole
pt has recently been on an antibiotic and now has "Red Man" syndrome...with extreme flushing... what did they take?
vancomycin
Bacitracin Bactericidal or static?
Bactericidal … NOT a beta lactam!!!
Bacitracin method of use?
topical
MOA for bacitracin?
inhibits carrier protien (bactoprenol) for cell wall building blocks
DOC for Kleb pneumonia?
ceftazidime