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47 Cards in this Set
- Front
- Back
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ovarian dysgerminoma
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- malignant
- hCG, LDH - like male seminoma - TURNER's - sheets of uniform cells |
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Choriocarcinoma ovarian
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- Rare but malignant
- develop during PREGO in MOM or Baby - hCG - large hyperchromatic syncytiotrophoblastic cells - inc feq of the THECA-LUTEIN cysts |
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Yolk Sac ovarian
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- endodermal sinus
- AFP - aggressive malignancy and sacrococygeal area of young children - YELLOW FRIABLE, SOLID MASS - 50% have SCHILLER-DUVAL bodies (resemble GLOMERULI) |
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Teratoma ovarian
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90% of ovarain germ cell tumors
- cells from 2 or 3 germ layers Mature teratoma "dermoid cyst" = most freq. ovarian tumor IMMATURE - aggressively malignant STRUMA OVARII = contain fxnal THYROID TISSUE = present at HYPERTHYROIDISM |
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Sarcoma botryoides
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-rhabdomyosarcoma of vagina
girls < 4 yrs DESMIN POSITIVE |
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Granulosa cell tumor
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- secretes Estrogen -> precocious puberty
- endometrial hyperplasia or carcinoma CALL-EXNER BODIES = small follicles filled w/ EOSINOPHILIC secretons. Abnormal uterine bleeding |
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Meig's
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FIBROMA
ASCITES HYDROTHORAX - pulling ssensation in groin |
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Brenner tumor
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surface derived ovarian tumor
- Benign - loks like BLADDER (transitional cell epithelium) |
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Serous ovarian tumor
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cystadenoma = benign
- 20% of ovarian tumors - BILATERAL - Fallopian tube-like epithelium CYSTADENOCARCINOMA - 50% of ovarian tumors MALIGNANT - freq. bilteral - PSAMMOA BODIES |
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Ovary tumor general
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inc CA-125
risk factor = BRCA-1; HNPCC Family hx most important risk factor |
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Mucinous ovarain tumor
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Cystadenoma = multilocular cyst
- benign - Intestine like tumor Cystadenocarcinoma = MALIGNANT PSEUDOMYXOMA PERITONEI - intraperitoneal accumulation of mucinosu material from ovarian or appendix tumor |
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pseudomyxoma peritonei
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Mucinous
ovaraian or appendix tumor |
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Increase free prostate-PSA
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BPH
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increase total PSA
decrease fraction of FREE PSA |
prostatic adenocarcinoma
- posterior lobe (peripheral zone) |
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cryptorchidism
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- undescended testes
heat -> lack of permatogenesis inc risk of germ cell tumors |
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Seminoma testes
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- malignant
- painless - FRIED EGG APPEARANCE |
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Embryonal carcinoma
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MALIGNANT
PAINFUL WORSE PROGNOSIS than seminoma GlANDULAR/PAPILLARY morphology Inc AFP and hCG |
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Yolk sac (endodermal sinus tumor)
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- Yellow, mucinous analogus to ovarian yolk sac
SCHILLER-DUVAL BODIES resembel PRIMITIVE GLOMERULI Increased AFP |
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Choriocarcinoma
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malignant
inc hCG |
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Leydig cell
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REINKE CRYSTALS
- ANDROGEN producing GYNECOMASTIA in men PRECOCIOUS PUBERTY Golden Brown color |
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varicocele
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dilated vein in pampiniform plexus
can cause INFERTILITY BAG of worms |
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Hydrocele
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inc fluid SECONDARY to incomplete fusion of
PROCESSUS VAGINALIS |
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Spermatocele
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dilated EPIDIDymal duct
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Bowen's penis
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- HPV 16
- gray, solitary, crusty plaque - 40s - INVOLVES SHAFT progress to invasive SCC in < 10% of cases |
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Erythroplasia of Queyrat
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-HPV 16
- RED VELVTY PLAQUES - involves GLANS |
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Bowenoid papulosis
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- Multiple papular lesions
YOUNGER AGE GROUP DOES NOT BECOME INVASIVE HPV 16 |
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Fibroadenoma
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BENIGN BREAST TUMORS
- small, mobile, firm, sharp edges < 25 yrs old INC SIZE and TENDERNESS w/ INC ESTROGEN (pregnancy or menstration) - not a precursor to cancer |
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Phyllodes tumor
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BENIGN BREAST TUMORS
- LARGE BULKY MASS of connective tissue and cysts - LEAF-LIKE PROJECTIONS 6th DECADE - some may become malignant |
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Intraductal papilloma
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BENIGN BREAST TUMOR
- Small tumor that grows in LACTIFEROUS DUCTS - TYpicallly beneath AREOLA SEROUS or BLOODY NIPPLE DISCHARGE - sligt risk for carcinoma (1.5 - 2x) |
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Fibrocystic disease
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- MCC of breast lumps
- premenstrual breast pain and multiple lesions, often bilateral - fluctuation in size - does not increase risk of carcinoma |
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Stroma tumors
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Fibroadenoma
Phyllodes tumor |
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lobule tumors
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sclerosing adenosis, lobular carcinoma
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lactifeous sinus tumor
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intraductal papilloma
breast abscess mastitis |
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Fibrosis
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Fibrocystic disease
- hyperplasia of breast stroma |
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Cystic fibrocystic disease
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- fluid filled
- blue dome - Ductal dilation |
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Sclerosing adenosis
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- fibrocystic disease
- inc acini and intralobular fibrosis - assoc w/ calcifications |
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Epithelial hyperplasia
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Fibrocystic disease
inc in number of epithelial cell layer in terminal duct lobule INC risk of CARCINOMA w/ ATYPICAL cells women >30 yrs |
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ERB-B2
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- HER-2 overexpression
- EGF receptor affects therapy and prognosis |
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BRAC1
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tumor suppressor
CHorm 17 = DNA repair - breast and ovary |
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BRAC2
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tumor suppressor
dna repair breast |
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DCIS breast
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- fills ductal lumen
- arises from ductal hyperplasia - early malignancy no BM penetration |
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Invasive ductal breast
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- firm, fibrous, "ROCK-HARD"
small, glandular, duct-like cells WORST AND MOST INVASIVE. Most common (76% breast cancer) ERBB2 |
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Invasive lobular breast
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Orderly row of cells "bulls eye"
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medullary breast carcinoma
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- Fleshy
- Cellular - LYMPHOCYTIC INFILTRATE - LARGE CELLS GOOD PROGNOSIS, BRCA1 |
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Comedocarcinoma breast
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- Dutal, caseous necrosis
subtype DCIS |
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Inflammatory breast carcinoma
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- lymphatic invasion
- Peau d-orange 50% survival in 5 yrs |
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Paget's disease
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- crusty red nipple
PAGET CELLS = cells in epidermis w/ CLEAR HALO suggest underlying carcinoma - also seen on vulva |
