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32 Cards in this Set
- Front
- Back
Biopsy of breast |
Normal Terminal Duct Lobular Unit (TDLU) of Breast
*Arrow points to lobule |
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Biopsy of breast |
Normal breast
*2-layers line duct: 1) Luminal Epithelial cells that make milk, 2) Myoepithelial cells that contract to expel milk |
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Biopsy of Breast |
Fibrocystic Change of Breast
*most common cause of lumpy-bumpy breast *Black points to fibrosis, green points to cysts (dilated ducts) lined with papillary epithelium (circle shows some papillary fingers) |
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Taken from a lumpy breast |
Cyst in Fibrocystic Change Disease
*lined w/ eosinophilic columnar/cuboidal epithelium w/ a slightly bubbly appearance (apocrine snouts) = "Apocrine Metaplasia" |
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Biopsy from breast |
Fibroadenoma
*well-circumscribed, mobile, palpable mass |
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Excised mass in breast |
Fibroadenoma
*Well-circumscribed mass *Most common benign leison - see in reproductive age |
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Excised mass in breast |
Fibroadenoma
*Proliferation and fibrosis of intralobular stroma (right) compresses ducts (left) |
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Excised mass in breast |
Ductal Carcinoma In Situ - Cribiform type
*Proliferation of ductal epithelial cells fill duct w/ regular "cookie-cutter" spaces = Cribiform
*Intact BM and myoepithelium = in situ |
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Excised mass in breast |
Ductal Carcinoma In Situ - Comedo type
*Proliferation of ductal epithelial cells fill duct w/ central area of necrosis = Comedo
*Intact BM and myoepithelium = in situ |
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Excised mass in breast |
Ductal Carcinoma In Situ - Papillary type
*Proliferation of ductal epithelial cells form finger-like papillae w/ fibrovasc. core = Papillary *Papillae w/out fibrovasc. core = Micropapillary
*Intact BM and myoepithelium = in situ |
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Excised mass in breast |
Ductal Carcinoma In Situ - Solid type
*Proliferation of ductal epithelial cells fill duct = solid *Arrow points to microcalicification
*Intact BM and myoepithelium = in situ |
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Excised mass in breast |
Invasive (aka Infiltrative) Ductal Carcinoma
*nests of malignant cells invade stroma and may form tubules (left) *Stroma undergoes fibroblastic response = Desmoplasia (right) -- makes tumor hard |
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Biopsy specimen from breast |
Invasive (aka Infiltrative) Ductal Carcinoma
*Radial Scar (thus not circumscribed) *~1% of DCIS/yr develop into invasive carcinoma |
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Biopsy Specimen from breast |
Invasive Lobular Carcinoma
*cells line in a single file instead of forming lobules *stain - for E-cadherins |
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Biopsy specimen from breast |
Medullary Breast Carcinoma
*Nests of malginant cells surrounded by stroma w/ lymphocytic infiltrate but little desmoplasia *Triple negative w/ hemorrage and necrosis but good prognosis |
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Inflammatory Carcinoma
*Invasive/Infiltrative carcinoma that invades dermal lymphatics to cause rash and swelling |
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Biopsy from nipple with eczema like rash |
Paget's Disease of the Breast
*Invasive adenocarcinoma that invades into epidermis to cause eczema-like rash on nipple. *Unlike paget's of the vulva, almost always associated with underlying cancer! |
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Cervical biopsy |
Cervix
*Endocervix (right) = columnar epithelium w/ rough red gross appearance *Exocervix (left) = Squamous epithelium w/ smooth pink gross appearance |
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Cervical Biopsy |
Metaplasia of Cervix
*Squamous epithelium (black) overlying normal columnar epithelium of endocervix (yellow) *Due to chronic cervicitis leading to acute & chronic inflammation (green points to lymphocytes) *Common after vaginal delivery |
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Cervical Biopsy |
Invasive Squamous Cell Carcinoma of Cervix
*Squamous epithelium dips into submucosa w/ islands of squamous cells deep in submucosa (arrow) that indicate that lesion is invasive *Due to chronic cervicitis from HPV |
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Cervical Biopsy |
Invasive Squamous Cell Carcinoma of Cervix
*Left points to keratin pearl (common in squamous cell carcinomas) *Right point to nuclear atypia and dysplasia |
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Endometrial sample |
Endometrial Polyp
*left points to polyp *right = endometrium |
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Endometrial sample |
Early Secretory Endometrium
*Indicated by sub-nuclear vacuoles creating "piano-key" appearance |
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Endometrial sample |
Proliferative Endometrial Gland
*Small lumen, Thick-Non-Vaculated Epithelium, Straight glands |
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Taken from a cystic mass on ovary |
Mature Cystic Teratoma
*Left = skin tissue, Middle = hair follicle, Right = Sebacecous gland *Benign |
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Taken from cystic mass on ovary |
Mucinous Papillary Tumor
*Mulitlocular cyst with papillary growths on epithelium. Filled with thick mucus |
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Taken from cystic mass on ovary |
Borderline Mucinous Papillary Tumor
*Goblet cells that are mucin secreting (notice vacuoles in the process of exocytosis) *Some nuclear atypia, but No evidence of stromal invasion = borderline |
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Removed testis |
Seminoma (left)
*Most common germ cell tumor in males -- analogous to dysgerminoma in females. Good prognosis! *Right = normal teste tissue |
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taken from mass in teste |
Seminoma
*Tumor made of round cells with clear cytoplasm w/ large oval nuclei w/ prominent nucleoli. Often have lymphocytic infiltrate (not shown) *looks similar to dysgerminoma microscopically |
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taken from mass in teste |
Choriocarcinoma
*large amount of hemorrhage! Syncytiotrophblasts visible at top border and cytotrophoblast closer to mass of RBCs *pt would have elevated hCG |
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Sample from needle biopsy of prostate |
Prostate Cancer
*Bottom arrow shows normal prostate glands while top shows invasive carcinoma |
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Biopsy of prostate |
Prostate Cancer
*Normal prostate glands w/ invading cancer cells below (arrow) |