• Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off
Reading...
Front

Card Range To Study

through

image

Play button

image

Play button

image

Progress

1/32

Click to flip

Use LEFT and RIGHT arrow keys to navigate between flashcards;

Use UP and DOWN arrow keys to flip the card;

H to show hint;

A reads text to speech;

32 Cards in this Set

  • Front
  • Back

Biopsy of breast

Normal Terminal Duct Lobular Unit (TDLU) of Breast



*Arrow points to lobule

Biopsy of breast

Normal breast



*2-layers line duct: 1) Luminal Epithelial cells that make milk, 2) Myoepithelial cells that contract to expel milk

Biopsy of Breast

Fibrocystic Change of Breast



*most common cause of lumpy-bumpy breast


*Black points to fibrosis, green points to cysts (dilated ducts) lined with papillary epithelium (circle shows some papillary fingers)

Taken from a lumpy breast

Taken from a lumpy breast

Cyst in Fibrocystic Change Disease



*lined w/ eosinophilic columnar/cuboidal epithelium w/ a slightly bubbly appearance (apocrine snouts) = "Apocrine Metaplasia"

Biopsy from breast

Fibroadenoma



*well-circumscribed, mobile, palpable mass

Excised mass in breast

Fibroadenoma



*Well-circumscribed mass


*Most common benign leison - see in reproductive age

Excised mass in breast

Fibroadenoma



*Proliferation and fibrosis of intralobular stroma (right) compresses ducts (left)

Excised mass in breast

Ductal Carcinoma In Situ - Cribiform type



*Proliferation of ductal epithelial cells fill duct w/ regular "cookie-cutter" spaces = Cribiform



*Intact BM and myoepithelium = in situ

Excised mass in breast

Ductal Carcinoma In Situ - Comedo type



*Proliferation of ductal epithelial cells fill duct w/ central area of necrosis = Comedo



*Intact BM and myoepithelium = in situ

Excised mass in breast

Ductal Carcinoma In Situ - Papillary type



*Proliferation of ductal epithelial cells form finger-like papillae w/ fibrovasc. core = Papillary


*Papillae w/out fibrovasc. core = Micropapillary



*Intact BM and myoepithelium = in situ

Excised mass in breast

Ductal Carcinoma In Situ - Solid type



*Proliferation of ductal epithelial cells fill duct = solid


*Arrow points to microcalicification



*Intact BM and myoepithelium = in situ

Excised mass in breast

Invasive (aka Infiltrative) Ductal Carcinoma



*nests of malignant cells invade stroma and may form tubules (left)


*Stroma undergoes fibroblastic response = Desmoplasia (right) -- makes tumor hard

Biopsy specimen from breast

Invasive (aka Infiltrative) Ductal Carcinoma



*Radial Scar (thus not circumscribed)


*~1% of DCIS/yr develop into invasive carcinoma

Biopsy Specimen from breast

Invasive Lobular Carcinoma



*cells line in a single file instead of forming lobules


*stain - for E-cadherins

Biopsy specimen from breast

Medullary Breast Carcinoma



*Nests of malginant cells surrounded by stroma w/ lymphocytic infiltrate but little desmoplasia


*Triple negative w/ hemorrage and necrosis but good prognosis

Inflammatory Carcinoma



*Invasive/Infiltrative carcinoma that invades dermal lymphatics to cause rash and swelling

Biopsy from nipple with eczema like rash

Paget's Disease of the Breast



*Invasive adenocarcinoma that invades into epidermis to cause eczema-like rash on nipple.


*Unlike paget's of the vulva, almost always associated with underlying cancer!

Cervical biopsy

Cervix



*Endocervix (right) = columnar epithelium w/ rough red gross appearance


*Exocervix (left) = Squamous epithelium w/ smooth pink gross appearance

Cervical Biopsy

Metaplasia of Cervix



*Squamous epithelium (black) overlying normal columnar epithelium of endocervix (yellow)


*Due to chronic cervicitis leading to acute & chronic inflammation (green points to lymphocytes)


*Common after vaginal delivery

Cervical Biopsy

Invasive Squamous Cell Carcinoma of Cervix



*Squamous epithelium dips into submucosa w/ islands of squamous cells deep in submucosa (arrow) that indicate that lesion is invasive


*Due to chronic cervicitis from HPV

Cervical Biopsy

Invasive Squamous Cell Carcinoma of Cervix



*Left points to keratin pearl (common in squamous cell carcinomas)


*Right point to nuclear atypia and dysplasia

Endometrial sample

Endometrial Polyp



*left points to polyp


*right = endometrium

Endometrial sample

Early Secretory Endometrium



*Indicated by sub-nuclear vacuoles creating "piano-key" appearance

Endometrial sample

Proliferative Endometrial Gland



*Small lumen, Thick-Non-Vaculated Epithelium, Straight glands

Taken from a cystic mass on ovary

Taken from a cystic mass on ovary

Mature Cystic Teratoma



*Left = skin tissue, Middle = hair follicle, Right = Sebacecous gland


*Benign

Taken from cystic mass on ovary

Taken from cystic mass on ovary

Mucinous Papillary Tumor



*Mulitlocular cyst with papillary growths on epithelium. Filled with thick mucus

Taken from cystic mass on ovary

Taken from cystic mass on ovary

Borderline Mucinous Papillary Tumor



*Goblet cells that are mucin secreting (notice vacuoles in the process of exocytosis)


*Some nuclear atypia, but No evidence of stromal invasion = borderline

Removed testis

Removed testis

Seminoma (left)



*Most common germ cell tumor in males -- analogous to dysgerminoma in females. Good prognosis!


*Right = normal teste tissue

taken from mass in teste

taken from mass in teste

Seminoma



*Tumor made of round cells with clear cytoplasm w/ large oval nuclei w/ prominent nucleoli. Often have lymphocytic infiltrate (not shown)


*looks similar to dysgerminoma microscopically

taken from mass in teste

taken from mass in teste

Choriocarcinoma



*large amount of hemorrhage! Syncytiotrophblasts visible at top border and cytotrophoblast closer to mass of RBCs


*pt would have elevated hCG

Sample from needle biopsy of prostate

Sample from needle biopsy of prostate

Prostate Cancer



*Bottom arrow shows normal prostate glands while top shows invasive carcinoma

Biopsy of prostate

Biopsy of prostate

Prostate Cancer



*Normal prostate glands w/ invading cancer cells below (arrow)