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8 Cards in this Set

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Finasteride
1)MOA
2)Use
1) 5-alpha reductase inhibitor (less testosterone --> DHT)

2) Benign Prostatic Hypertrophy, Male Pattern Baldness (low dose)
Flutamide
1)MOA
2)Use
1) Nonsteroidal competitor of androgens at Testosterone receptor

2)Trt for androgen dependent prostate cancer
Ketoconazole, Spironolactone
1)MOA
2)Use
1) Inhibit steroid synthesis

2) Polycystic Ovarian Syndrome to prevent Hirsutism
Sildenafil, Vardenafil
1)MOA
2)Use
3)Toxicity
1)Inhibits cGMP phosphodiesterase causing increase cGMP --> smooth muscle relaxation in corpus cavernosum --> increase blood flow --> penile erection

2) Erectile Dysfunction

3) Headache, flushing, dyspepsia, blue green vision, Risk of life threatening Hypotension in pts on Nitrates
Leuprolide
1)MOA
2)Use
3)Toxicity
1) GnRH analog with agonist properties when used in pulsatile fashion and antagonist properties when used in continuous fasion

2)Infertility (pulsatile), prostate cancer (continuous- in addition to flutamide), and uterine fibroids

3) Antiandrogen, nausea, vomiting
Clomiphene
1)MOA
2)Use
3)Toxicity
1) Partial agonist at estrogen receptor in Pituitary --> prevents normal feedback and allows larger release of LH and FSH --> stimulates Ovulation

2) Infertility

3) Hot flashes, ovarian enlargement, multiple pregnancies, visual problems
Mifepristone (RU-486)

1)MOA
2)Use
3)Toxicity
1) Competitive inhibitor of progestins at progesterone receptors and causes uternine contractions

2)Pro-abortant

3) Heavy Bleeding, GI effects, Ab pain
Oral Contraception
1)MOA
2)Advantages
3)Disadvantages
1) Maintains constant low levels of estrogen/progesterone to prevent LH spike and ovulation

2) Reliable, Low risk of infxns, regular menses

3) No STD protection, depression, weight gain, hypertension, hypercoagulable