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29 Cards in this Set
- Front
- Back
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Which cells in the testis produce testosterone?
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Leydig cells
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The testis produce which 2 hormones?
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1. Testosterone
2. 5a-DHT |
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The adrenal produce which 2 hormones?
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1. Androstenedione
2. Dehydroepianandrosterone (DHEA) |
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The adrenal hormones contribute to what?
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Male pubertal changes - hair growth and maturation
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What is the most commonly used supplement in men to increase sexual performance and sense of well being?
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DHEA
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Most of circulating testosterone is found bound to what 2 proteins?
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1. SHBG
2. Albumin |
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In many target tissues testosterone is converted to what?
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5a-DHT
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Testosterone gets converted to what in adipose tissue and liver by aromatase?
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Estradiol
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What hormone stimulated steroidogenesis in leydig cells?
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LH
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What hormone stimulated spermatogenesis in seminiferous tubules?
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FSH
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What plays a key regulatory role in binding of Androgen receptor complex to response element in gene?
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Co-activator ARA70
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Do Testosterone and 5a-DHT bind to the same receptor?
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Yes, AR (androgen receptor)
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What are 4 negative effects of 5-DHT?
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1. Acne
2. Scalp hair recession 3. Prostate enlargement 4. Decrease HDL |
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Pro-androgen therapy consists mainly of what?
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exogenous androgens (receptor agaonists)
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Anti-androgen therapy consists of what 2 elements?
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1. Receptor antagonists
2. Synthesis blockers |
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What are the 4 indications for the therapeutic use of synthetic androgens?
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1. Androgen Replacement Therapy (Hypogonadism, aging)
2. Protein Anabolic Effects (catabolic disorders assocaited with ling term illness) 3. Anemia (increases Epo) 4. Anabolic steroids in athletes |
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Esterification at which position synthesizes complete androgen with comparable potency to testosterone?
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17B-position
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What at the 17-a position synthesizes androgens with more pronounced anabolic properties?
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Alkylation at the 17a position
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Synthesis inhibition in Anti-androgen therapy consists of blocking which enzyme?
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5a-reductase inhibition
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What is a drug example of synthesis inhibition of testosterone?
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Finasteride
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What are three receptor antagonists in anti-androgen therapy?
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1. Flutamide
2. Cyproterone 3. Spironolactone |
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Which isoform of 5a-reductase has the following properites:
1. Low expression in Prostase 2. Low expression in hair follicles 3. High expression in sebaceous glands |
Type 1
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Which isoform of 5a-reductase in potently inhibited by finasteride?
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Type 2
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Finsteride has a high potency for Type 2 isoform of 5a-reductase, does that make it a good treatmen for acne?
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NO
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Is finasteride a good treatment for BPH?
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YES
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Which 5a-reductase isoform must be blocked to treat BPH?
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Type 2
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Daily dosing of what reduces serum DHT by ~70%?
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Finasteride
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Did finasteride positively affect balding?
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YES, men showed increased hair counts in studies
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What are 2 hormonal treatments for prostatic cancer?
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1. Flutamide/nilutamide
2. Cyproterone acetate |
