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6 Cards in this Set

  • Front
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Estradiol
1. Origin
2. Negative Feedback
3. Positive Feedback
4. Local effect on follicle
1. FSH stimulates Granulosa cells to aromatize androstenedione to estradiol

2. Negative feedback at anterior pituitary suppresses FSH release

3. Positive feedback at anterior pituitary stimulates LH release

4. Estradiol increases FSH receptors on granulosa cells
GnRH
1. Origin
2. Action
1. Pulsatile release from arcuate nucleus into portal circulation

2. Stimulates FSH release from anterior pituitary
FSH
1. Origin
2. Action
3. Structure
1. Anterior pituitary

2. stimulates aromitization of androstenedione to estradiol in granulosa cells

4. Large glycoprotein
LH
1. Origin
2. 4 Actions
3. Structure
1. Anterior Pituitary

2. Stimulates androstendione synthesis in theca cells. Continuation of meiosis. Luteinization of granulosa cells. Prostaglandin synthesis

3. large glycoprotein; short half life; similar structure to HCG; pulsatile
Progesterone
1. Origin
2. Action
3. Half life
1. Corpus Luteum

2. Changes endometrium from proliferative to secretory

3. Fixed half-life of 14 days unless HCG is present
3 Stages of Menstruation
1. Proliferation: caused by unopposed estrogen ??Day 4-15??

2. Secretory: caused by progesterone ??Day 16-27??

3. Menses: withdrawal bleed ??Day 28-3??