*repro Week 1: Intro To Menstruation

Front 1

Estradiol
1. Origin
2. Negative Feedback
3. Positive Feedback
4. Local effect on follicle

Back 1

1. FSH stimulates Granulosa cells to aromatize androstenedione to estradiol

2. Negative feedback at anterior pituitary suppresses FSH release

3. Positive feedback at anterior pituitary stimulates LH release

4. Estradiol increases FSH receptors on granulosa cells

Front 2

GnRH
1. Origin
2. Action

Back 2

1. Pulsatile release from arcuate nucleus into portal circulation

2. Stimulates FSH release from anterior pituitary

Front 3

FSH
1. Origin
2. Action
3. Structure

Back 3

1. Anterior pituitary

2. stimulates aromitization of androstenedione to estradiol in granulosa cells

4. Large glycoprotein

Front 4

LH
1. Origin
2. 4 Actions
3. Structure

Back 4

1. Anterior Pituitary

2. Stimulates androstendione synthesis in theca cells. Continuation of meiosis. Luteinization of granulosa cells. Prostaglandin synthesis

3. large glycoprotein; short half life; similar structure to HCG; pulsatile

Front 5

Progesterone
1. Origin
2. Action
3. Half life

Back 5

1. Corpus Luteum

2. Changes endometrium from proliferative to secretory

3. Fixed half-life of 14 days unless HCG is present

Front 6

3 Stages of Menstruation

Back 6

1. Proliferation: caused by unopposed estrogen ??Day 4-15??

2. Secretory: caused by progesterone ??Day 16-27??

3. Menses: withdrawal bleed ??Day 28-3??