Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
7 Cards in this Set
- Front
- Back
|
Pharmacologic effect of HC's:
Drug that is on a ring of steroids, slowed hepatic degradation, 15-20x more active than estradiol: What is Mestranol? Estrogens are highly bound to what in the blood? |
modify midcycle FSH/LH surge - inhibits HPA axis, ovulation; diminish ovarian hormones, endometrial changes unfavorable to implantation, thickens cervical mucus
ethinyl estradiol metabolized to ethinyl estradiol SHBG |
|
|
Progestins are highly protein bound to what?
Which progestin has anti-mineralocorticoid and anti-androgenic properties? Progestin in: Patch, Vaginal ring, implant, Depo shot: |
albumin, also SHBG - except Drospirenone
Drospirenone patch - norelgestromin ring, implant - etonogestrel Depo injection - medroxyprogesterone |
|
|
Advantages, Disadvantages of combo pill oral contraceptives:
Which patients should use a progestin-only pill? Difference between monophasic, biphasic, triphasic OC's: |
effective, health benefits, allows patient control
must take daily, SE's --> D/C, rare risk of blood clots, stroke smokers >35 y/o, vascular disease, breast ca, HTN mono - fixed dose of E, P through cycle bi - fixed E dose, 1st half E/P ratio decreases, 2nd half increased tri - increased E, P through cycle |
|
|
4 extended-cycle drugs:
Ortho-Evra (patch): How long is the vaginal ring in place for? How long is the progestin implant (etonogestrel) effective for? |
Seasonale, Seasonique, Yaz, Loestrin 24 Fe
norelgestromin/EE; weekly application; 1 patch/week for 3 weeks 3 weeks 3 years |
|
|
How often do you need to get the Depo-Provera shot? Disadvantages?
How long is an IUD (Mirena) effective for? |
3 months - irregular bleeding, amenorrhea, weight gain, abd pain, depression, decreased bone mass
5 years |
|
|
Serious SE's of contraceptives:
Mild SE's: What drugs have a risk of hyperkalemia? Drug with anti-mineralocorticoid effects: effect on fluid retention? |
VTE, MI/stroke, HTN, GB disease, hepatic function changes, ocular lesions (thrombosis), PID w/ IUDs
irregulat bleeding, glucose intolerance, lipid changes, depression, fluid retention, breast tenderness, GI, HA Yasmin/Yaz, drospirenone drospirenone increases Na+, H2O EXCRETION, K+ retention |
|
|
When should you take the Plan B/Preven pill?
Progestin-only contraception: Health benefits of OC pills: |
1st dose ASAP (within 72h) of unprotected sex; 2nd dose, 12 h later
more effective/fewer SE's than combined high dose OC - inhibits ovulation/fertilization, DOES NOT induce abortion if pregnant regulate period, reduced risk of cancers, prevents bone loss, PID, ectopic pregnancy, tx of acne, hirsutism |
