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13 Cards in this Set

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embryonic derivation of ovarian stromal cells
retroperitoneal mesenchyme
ovarian stroma cells include the following types...
granulosa (surround oocyte)
theca (surround granulosa)
embryonic derivation of ovarian germ cells
allantois?
migrate thru yolk sac to retroperitoneal mesenchyme
mimic appendicitis
at risk for ovarian torsion
follicle cyst

includes BOTH granulosa & theca
sclerocystic ovarian change found in...
POCS
Stein-Leventhal Syndrome
Mullerian cell types
serous (fallopian tube)
endometrial
endocervical (mucus)
source of epithelial ovarian tumors
epithelial inclusion cyst
types of epithelial ovarian neoplasms
serous
-cystadenoma (benign)
-serous carcinoma
-borderline serous (transition between the two)

Mucinous
-pseudomyxoma peritonei
-mets from appendix/colon

Endometrioid tumors
-often coexist w/uterine

Clear Cell Carcinoma

Transitional Cell Tumors (Brenner): benign, bladder epi
sex cords give rise to...
sertoli & leydig
granulosa & theca

(from mesenchyme)
non-functional ovarian stromal tumors
ovarian fibroma (middle age, rare under 30, no steroid production)
-Meig's syndrome: ascites & pleural effustion

fibroma-thecoma (stroma + thecal cell)
functional ovarian stromal tumors
Granulosa cell tumors
-estrinemia, usually benign
-abnormal bleeding, endometrial hyperplasia, carcinoma
-post menopausal

Thecoma
-lipid laden stromal or thecal cells
-estrinemia, unilateral
-abnormal bleeding, hyperplasia, carcinoma
-Meig's syndrome

Sertoli-Leydig cell tomors (rare in ovary)
-androgenic in 30% of cases
-young women (avg 25 yrs)
Germ Cell Tumor types
Teratomas
-mature cystic: benign, "dermoid cysts", teeth
-malignant transformation: rare, squamous cell carcinoma
-immature: young women, malignant, mets via implantation & lymph
-Monodermal: 1 tissue type, struma ovarii & ovarian carcinoid

Dysgerminoma:
-like seminoma
-malignant, respond well to radiation
-most common malig ovarian tumor

Endodermal Sinus Tumor (yolk sac tumor):
-AFP & alpha antitrypsin
-rare
-younger than 30

Choriocarcinoma:
- beta hCG
-gestational or non-gestational
-malignant trophoblasts
eosinophilic globule in cell cytoplasm
alpha fetoprotein