Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
29 Cards in this Set
- Front
- Back
|
primary sex cord development (how many weeks)
|
5th week
mesothelial prolifereation |
|
|
differentiation at week 2
|
epiblast (embryo)
hypoblast (yolk sac) |
|
|
differentiation at week 3
|
epiblast dvp primitive streak
endoderm cells migrate mesoderm cells migrate |
|
|
differentiation at week 4
|
mesoderm into paraxial, intermediate, lateral plate
ecto into neural tube endo folding into gut tube & glands (liver, pancreas, etc) |
|
|
paraxial meso differentiates into
|
dermis, skin, muscle, spinal cord
via somites |
|
|
intermediate meso differentiates into
|
UG system
|
|
|
lateral plate differentiates into
|
body wall, wall of gut, limbs
|
|
|
function of SRY
|
transcription factor
expressed in genital ridge sertolis produce MIS leydigs produce testosterone |
|
|
androgens produced at
|
9-12 weeks
|
|
|
genital differentiation seen at
|
9-12 weeks
|
|
|
oocytes proliferate until
|
4 months gestation
|
|
|
gonadal descent begins at
|
7 months gestation
|
|
|
hypospadius associated with
|
curvature of penis
(ventral/inferior) |
|
|
epispadius associated with
|
bladder extrophy
(dorsal/superior) |
|
|
seminiferous tubules homologous with
|
follicles
|
|
|
mesonephric tubules differentiate into...
|
eoophoron/efferent ductules
|
|
|
genital folds differentiate into...
|
labia minora/floor of penile urethra
|
|
|
genital swellings differentiate into...
|
labia majora/scrotum
|
|
|
genital tubercle develops into...
|
clitoris/penis
|
|
|
wolfian duct structures
|
opiod structures
seminal vessicles vas deferens |
|
|
muellarian duct structures
|
fallopian tubes
uterus upper 1/3 vagina |
|
|
hormones required for male differentation
|
MIS
testosterone DHT |
|
|
role of testosterone
|
maintain wolfian duct
(seminal vesicles & vas & opiods) |
|
|
role of DHT
|
external genitalia
prostate male urethra |
|
|
testicular descent requires
|
MIS
androgens intra abdominal pressure |
|
|
puberty hormones
|
testosterone
-deepen voice -penis growth DHT -beard -MP baldness -prostate maturation adrenal androgens -axillary & pubic hair |
|
|
female with ambiguous genitalia
|
CAH (21 hydroxylase insuff)
-normal XX -elevated androgens -virulized genitalia -psychosoc unclear 5 alpha reductase defic - normal XY -testes -testosterone -psychosocial femal til puberty |
|
|
infertil femal/no menses
|
Turners
-XO female SRY- male -ovary & estrogen -blind vagina -psychosocial female AI male -SRY + -testes & testosterone -psychosocial female |
|
|
feminized males
|
Kleinfelter's
-XXY male -infertil -cryptorchidism Kallman syndrome -failed neuronal migration -GnRH failure -normal male til puberty -eunichoid after puberty -infertile KF variant -XX male -SRY positive -normal gonads & hormones |
