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29 Cards in this Set

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  • Back
primary sex cord development (how many weeks)
5th week

mesothelial prolifereation
differentiation at week 2
epiblast (embryo)
hypoblast (yolk sac)
differentiation at week 3
epiblast dvp primitive streak
endoderm cells migrate
mesoderm cells migrate
differentiation at week 4
mesoderm into paraxial, intermediate, lateral plate

ecto into neural tube

endo folding into gut tube & glands (liver, pancreas, etc)
paraxial meso differentiates into
dermis, skin, muscle, spinal cord

via somites
intermediate meso differentiates into
UG system
lateral plate differentiates into
body wall, wall of gut, limbs
function of SRY
transcription factor
expressed in genital ridge
sertolis produce MIS
leydigs produce testosterone
androgens produced at
9-12 weeks
genital differentiation seen at
9-12 weeks
oocytes proliferate until
4 months gestation
gonadal descent begins at
7 months gestation
hypospadius associated with
curvature of penis
(ventral/inferior)
epispadius associated with
bladder extrophy
(dorsal/superior)
seminiferous tubules homologous with
follicles
mesonephric tubules differentiate into...
eoophoron/efferent ductules
genital folds differentiate into...
labia minora/floor of penile urethra
genital swellings differentiate into...
labia majora/scrotum
genital tubercle develops into...
clitoris/penis
wolfian duct structures
opiod structures
seminal vessicles
vas deferens
muellarian duct structures
fallopian tubes
uterus
upper 1/3 vagina
hormones required for male differentation
MIS
testosterone
DHT
role of testosterone
maintain wolfian duct
(seminal vesicles & vas & opiods)
role of DHT
external genitalia
prostate
male urethra
testicular descent requires
MIS
androgens
intra abdominal pressure
puberty hormones
testosterone
-deepen voice
-penis growth

DHT
-beard
-MP baldness
-prostate maturation

adrenal androgens
-axillary & pubic hair
female with ambiguous genitalia
CAH (21 hydroxylase insuff)
-normal XX
-elevated androgens
-virulized genitalia
-psychosoc unclear

5 alpha reductase defic
- normal XY
-testes
-testosterone
-psychosocial femal til puberty
infertil femal/no menses
Turners
-XO female

SRY- male
-ovary & estrogen
-blind vagina
-psychosocial female

AI male
-SRY +
-testes & testosterone
-psychosocial female
feminized males
Kleinfelter's
-XXY male
-infertil
-cryptorchidism

Kallman syndrome
-failed neuronal migration
-GnRH failure
-normal male til puberty
-eunichoid after puberty
-infertile

KF variant
-XX male
-SRY positive
-normal gonads & hormones