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14 Cards in this Set

  • Front
  • Back
Conjugated Estrogens
Estradiol
Ethinyl estradiol
SERM
Raloxifene
Estrogen Inhibitor
Anastrozole
Progestins
Medroxyprogesterone
Norethindrone
Levonorgestrel
Progesterone
GnRH agonists
Leuprolide
Goserelin
Nafarellin
Anti-Androgen
Flutamide
Finasteride
Spironolactone
Estradiol
Ethinyl estradiol
MOA - receptor interaction -> gene transcription
Uses - postmenopausal HRT (prevent vasomotor sxs), hormonal contraception
CI - estrogen dep neoplasms, endometriosis, adolescent girls, pregs
Raloxifene
MOA - agonists/antagonists on estrogen receptor - agonist in bone, antagonists in breast/uterus
Uses - prevention of breast cancer
Tox - menopausal sxs, bone loss!
Anastrozole
MOA - selective inhibitor of aromatase
Uses - post menopausal women w/ hormone receptor pos for breast cancer, relieves postmenopausal ab pain from endometriosis
AE - hot flases, osteoporosis
Medroxyprogesterone
Norethindrone
Levonorgestrel
Progesterone
Dx uses - test for estrogen secretion
Tx uses - hormonal contraception, endometriosis, DUB, dysmenorrhea, inc fertility, advanced breast and endometrial carcinoma
Leuprolide
-> gonadal suppression
Uses - tx of prostatic carcinoma, rapid relief from endometriosis
AE - bone loss
Flutamide (antagonist)
MOA - competitive antagonist at androgen receptor
Uses - prostatic cancer
Finasteride (inhibitor)
MOA - inhibits the 5-alpha reductase
Uses - BPH, hirsutism
Spironolactone
Uses - hirsutism in females w/ PCOS