Repro Drug/procedure Mechanisms

Front 1

uterine aspriation

Back 1

electric/manual vacuum aspiriation;

Front 2

medical abortion

Back 2

abortion caused through medicines including mifepristone/misoprostol or methotrexate/misoprostol or misprostol alone

Front 3

mifepristone (RU486)

Back 3

anti-progestin (blocks progesterone as a type 2 antagonist; ligand binds to receptor --> complex binds to HRE --> recruits co-repressor --> no gene transcription); decidual necrosis, rhymic uterine contractions, cervical ripening --> detachment/expulsion

Front 4

misoprostol

Back 4

prostaglandin e1 analog; causes uterine contractions; softens + primes cervix, prevents/treats ulcers, can lead to nausea/vomitting, diarrhea, fever, and chiills

Front 5

methotrexate

Back 5

anti-folate --> blocks division of rapidly diving cells by inhibiting DNA synthesis --> affects cytotrophoblast ccells and impairs implantation

Front 6

Instillation

Back 6

instill fluid into uterus to increase in girth and lead to contractions

Front 7

Induction

Back 7

prostaglandins + oxytocin as needed; deliver intact fetus w/ procedure for extraction of placenta

Front 8

Dilation + Evacuation (D+E)

Back 8

cervical prep (osmotic dilators like laminaria japonica, lamicel, dilapan; exert gentle radial pressure on endocervical canal, increase release of prostaglandins, pharmacological agents like mifepristone + misoprostol); suction and extraction to remove pregnancy parts; feocidal techniques with injectons of Kcl or digoxin)

Front 9

PDE 5 Inhibitors

Back 9

cGMP phosphodiesterase inhibitors (stops breakdown); maintain vasodilator response (still need nerves to initiate)

Front 10

Ethinyl estradiol/mestranol

Back 10

estrogen

Front 11

equilin/equilenin

Back 11

estrogen

Front 12

raloxifene

Back 12

SERM (selective estrogen receptor modulator) type 3; SERM binds to ER --> complex binds to estrogen response element in the nucleus --> conformation of complex determines whether an activator or a repression

Front 13

tamoxifen

Back 13

SERM (selective estrogen receptor modulator) type 4

Front 14

letrozole, vorozole, arimidex

Back 14

aromatase inhibitor (anti-estrogen)

Front 15

norethindrone

Back 15

progestin

Front 16

17B-esters of testosterone

Back 16

ong acting, potent synthetic complete androgen

Front 17

17a-alkylated androgens

Back 17

less potent as androgens than B; anabolic

Front 18

cyproterone acetate

Back 18

steroidal androgen receptor antagonist

Front 19

flutamide

Back 19

non-steroidal androgen receptor antagonist

Front 20

finasteride (proscar)

Back 20

5-alpha reductase inhibitor type 2

Front 21

leuprolide/Zoladex

Back 21

LH-RH agonist

Front 22

Male Condom

Back 22

barrier (latex, polyurethane, sheep membrane)

Front 23

Spermicides

Back 23

chemical barrier, nnoxynol-9 + delivery base (surfactant that disrupts sperm membrane

Front 24

Cervical Cap

Back 24

plastic cap fit into cervix

Front 25

Copper IUD (Permaguard)

Back 25

alters membrane and prevents gametes from implanting

Front 26

fertility awareness based methods

Back 26

most likely to get pregnant 6 days before to 1 day after ovulation

Front 27

Yuzpe regimin

Back 27

emergency contraception; 2 doses of EE w/ norgestrel given 12 hrs apart; first dose w/i 120 hrs of unprotected intercourse

Front 28

Progestin-only pill/plan B/levonorgestrel

Back 28

emergency contraception; 1 doese of 1.5 mg EE w/i 120 hrs of unprotected sex

Front 29

Ulipristal acetate (ella)

Back 29

progesterone receptor modulator that's likely to inhibit or delay ovulation

Front 30

Estrogen + Progestin OC

Back 30

progestin (inhibits LH surge/ovulation, thickens cervical mucus, endometrial atrophy); estrogen (inhibits FSH surge, follicle devo, thins cervical mucus, increases endometrial proliferation); less androgen stimulation (less free T/DHT --> lower LH/FSH --> less AR stimulation --> decreased acne/hersitism

Front 31

Extended Cycle Pill (Seasonale)

Back 31

levonogestrel +EE

Front 32

365-day pill

Back 32

levonogestrel +EE

Front 33

contraceptive patch

Back 33

norgestimate + EE

Front 34

Vaginal Ring

Back 34

eonogestrel + EE

Front 35

Levonorgestrel IUD (Mirena)

Back 35

levonogestrel (progestin only IUD)

Front 36

Implanon

Back 36

etonogestrel in implant under arm (no estrogen)

Front 37

olaparib

Back 37

PARP inhibitor (PARP usually helps with base excision repair; lack of PARP allows normal cells to survive b/c of other repair mechanisms but potentially cancerous cells die b/c they can't repair their DNA)