Repro: 3. Schriefer : Androgens

Front 1

what releases testosterone in males? females?

Back 1

males: LH-->Leydig cell of teste-->Testosterone

females: Adrenals/ovaries (theca cell)

Front 2

what are the 2 major physiological/pharmacological actions of testosterone?

Back 2

Testis and accessory structures:
Promote growth, maturation, and function of seminal vesticles, prostate and bulbourethral glands and external genitalia. Required for spermatogenesis. Also promote development of secondary sexual characteristics

Anabolic effects:
Promote nitrogen retention; increased muscle size and strength, bone growth, red cell maturation and erythropoietin production, decreased HDL

Front 3

does testosterone undergo first pass effect if given orally?

Back 3

yesssss sirrrrr

Front 4

Oxandrolone has what kind of activity

*

Back 4

mostly anabolic (think muscle, bone, red cell growth)

Front 5

Nandrolone has what kind of activity

Back 5

mostly anabolic (think muscle, bone, red cell growth)

Front 6

Stanozolol has what kind of activity

*

Back 6

mostly anabolic (think muscle, bone, red cell growth)

Front 7

What androgen drugs do you have to worry about hepatotox? (4)

*

Back 7

Methyltestosterone (androgen)

Fluoxymesterone (anabolic)

Oxandrolone (anabolic)

Stanozolol (anabolic)

Front 8

Adverse reactions of androgens?

Back 8

Masculinization
Growth disturbance
Edema
Jaundice, hepatitis, hepatic carcinoma – oral steroids, e.g., methyltestosterone and oxandrolone
Decreased spermatogenesis
Feminization
Behavioral changes
Tendon rupture
Increased serum PSA

Front 9

how do you get Decreased spermatogenesis with taking androgens?

Back 9

negative feedback turns off FSH which is necessary for spermatogenesis

Front 10

how do you get Feminization with androgen use?

Back 10

conversion to estrodiol

Front 11

if you are taking an androgen, what do you have to make sure not to take with it? 2

Back 11

Warfarin: increased bleeding

Echinacea: increased hepatotox

Front 12

Therapeutic Uses of androgens? 3 big ones

Back 12

Hypogonadism – replacement therapy in men (testosterone ester)

Stimulation of growth – in conjunction with GH (testosterone ester)

Protein anabolic agents – reverse protein loss after trauma, surgery, or prolonged immobilization

Front 13

what type of drug is flutamide? used to tx (3)? side effects? (2)

*

Back 13

Androgen receptor antagonists

Used to treat hirsutism in women, excessive sexual drive in men (for criminal offenders), and prostate cancer

can cause gynecomastia and mild hepatotoxicity (reversible)

Front 14

what type of drug is spironolactone? used to treat?


*****

Back 14

Androgen receptor antagonists (also a K sparing diuretic)

Used to treat hirsutism in women, excessive sexual drive in men, and prostate cancer

Front 15

what type of drug is Finasteride? used to treat?

Back 15

Inhibitors of 5 a-reductase; action results in decreased conversion of testosterone to dihydrotestosterone (DHT, which has a larger androgenic effect than testosterone--thanks first aid!).

Used in the treatment of benign prostatic hyperplasia (BPH).

Front 16

what type of drug is dutasteride? used to treat?

Back 16

Inhibitors of 5 a-reductase; action results in decreased conversion of testosterone to dihydrotestosterone.

Used in the treatment of benign prostatic hyperplasia (BPH).

Front 17

side effect of finasteride and dutasteride?

Back 17

Decreased libido and impotence are side effects

remember:

Inhibitors of 5 a-reductase; action results in decreased conversion of testosterone to dihydrotestosterone.

Used in the treatment of benign prostatic hyperplasia (BPH).

Front 18

use of ketoconazole?

Back 18

Antifungal drug which inhibits steroid synthesis. Used to prevent hisutism in polycystic ovarian disease, but toxicity limits its use.

Front 19

what is the GnRH analog used in the tx of prostate cancer?

Back 19

Leuprolide