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18 Cards in this Set
- Front
- Back
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Definite risk factors of prostate CA
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Age
Race (AA>Cauc>others) Family hx |
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Things that AREN'T risk factors
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STD, BPH, vasectomy, sexual activity, tobacco
However, smokers and obese do worse once they get prostate CA |
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Note abt this lecture.
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I didn't listen to all of it. When you study for the final, focus on the summary slides at the end - he said those are the key.
And quickly run through the ppt just to make sure you didn't miss anything. |
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Where do cancers in prostate develop?
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75% in peripheral zone, 15% in central, 10% in transitional.
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Which zones almost never have prostate CA?
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anterior and periprostatic sphincter zone
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Hormonal therapy
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Used for metastatic disease
Relieves pain and reduces PSA level. Effects can last for up to a year but then you need to try another option. Surgical castration and chemical castration (using hormonal therapy) are equivalent. |
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Chemotherapy summary
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Can relieve pain and reduce PSA
Prolongs survival, but is not curative. There is no role for bone marrow transplant!!! THIS IS THE LAST LINE OF THERAPY |
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Summary of prostate cancer
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#2 cancer in men
Incidence and survival has improved in past few years Controversial that improved survival is attributed to increased PSA testing. |
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Does an abnormal PSA always mean someone has prostate CA?
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no
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Pattern of spread of prostate CA
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Aside from this pattern, other sites of spread are very very rare.
Prostate to lymph nodes draining prostate to bones (now very painful) to lungs (very late) and then extremely rarely goes to the liver. |
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Races most/least affected
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Highest in AAs, lowest in Asian Americans of Chinese/Japanese descent
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Gleason score of ___ is bad
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>7
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If you feel a prostate nodule...
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YOU HAVE TO BIOPSY IT!
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Workup of prostate CA
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CT/MRI and bone scan and prostate biopsy
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Local disease - how to tx
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surgery or XRT or just watch and wait.
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After prostate has been removed...
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PSA should be 0.
If > 0.5, surgery was not complete or there is a met |
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Metastatic disease tx
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Castration first (either surgery or hormones) and then try chemo
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What is hormone therapy?
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A way of doing prostate castration.
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