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18 Cards in this Set
- Front
- Back
Which receptors does vasopressin bind to?
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V1 and V2
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Which receptors does desmopressin bind to?
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Selective for V2
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Routes of administration for desmopressin?
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IV, SC, *oral*
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Which vasopressive agent acts long?
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Desmopressin
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Can vasopressin be given orally?
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No, peptides will be broken down
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Vasopressin stimulates V2 on the collecting duct. What is the cascade that increases aquaporin channels?
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Gs --> Adenlyly cyclase --> cAMP --> PKA --> water channels
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Where are V1 receptors found?
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Vascular smooth muscle
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Where are V2 receptors found?
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Renal collecting duct
Vascular endothelium (release clotting factors) |
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What can stimulate ADH/vasopressin release?
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hypotension
hypovolemia increased plams osmolarity |
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How is vasopressin used clincally?
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ACLS
Vasodilatory shock |
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How is desmopressin used clincally?
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Nocturnal enuresis
Hemophilia A or Type 1 von Willebrand's dx Central diabetes insipidus |
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Can desmopressin be used for nephrogenic diabetes insipidus?
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No
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What is tx for nephrogenic diabetes insipidus?
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Thiazide diuretics
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What are some adverse reaction to vasopressin?
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Facial pallor
Transient headache Nausea, abdominal cramps (increase GI activity) |
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What type of electrolyte imbalnce is caused by desmopressin?
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Euvolemic hyponatruiemia
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Is intranasal desmopressin recommended for bed wetting?
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No
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What are some adverse reaction to intranasal desmopressin?
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Congestion
Rhinitis |
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Name the layers of the glomerular capillary wall from lumen to urinary space
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Mesangial cells
Endothelium Basement Membrane Podocytes |