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26 Cards in this Set
- Front
- Back
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What is the target of SMX/TMP?
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Antimetabolite --> blocks folate synthesis
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Which ABX is likely to cause kernicterus?
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SMX/TMP
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Which ABX is likely to cause Acute Hemolytic Anemia in a G6PD deficient pt?
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SMX/TMP and Nitrofurantoin
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Which ABX is likely to cause achilles tendon rupture?
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FQs
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What is the target of FQs?
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block DNA gyrase and Topoisomerase IV
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Which ABX form reactive species that damage bacterial DNA?
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Urinary antiseptics (nitrofurantoin)
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What are the FQs?
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Ciprofloxacin, Moxifloxacin, Levofloxacin, Norfloxacin
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What are the AGs?
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Gentamicin, Tobramycin, Amikacin, Neomycin, Streptomycin
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What are the Tetracyclines?
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Doxycycline, Minocycline, Tigecycline
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What are the Streptogramins?
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Quinupristin, Dalfopristin
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What are the Macrolides?
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Erythromycin, Azithromycin, Clarithromycin
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Which ABX is most likely to produce nephrotoxicity?
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AGs
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Which ABX is associated with Gray Baby syndrome?
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Chloramphenicol
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What is the target of chloramphenicol?
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50S blocks peptide bond formation
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Which ABX produce pseudomembranous colitis?
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Clindamycin and tetracyclines
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Which ABX inhibit MAO?
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Linezolid
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Which ABX are potent CYP3A4 inhibitors?
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Streptogramins
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Which ABX chelate with cations, get into bone and stain teeth?
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Tetracyclines
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Which ABX have a unique resistance mechanism where bac proteins compete with the drug for binding?
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Tetracyclines
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Which ABX could be used against pseudomonas?
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AP Pen, 3rd gen AP ceph, imipenem, tobramycin, aztreonam, ciprofloxacin
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Which drugs are effective against E. faecalis and faecium?
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Linezolid, Daptomycin
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Which ABX are eliminated metabolically?
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Macrolides, Streptogramins, Linezolid
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Which ABX is likely to cause red man syndrome?
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Vancomycin
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Which ABX are effective against MRSA?
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Vancomycin, Streptogramins, Linezolid, Daptomycin
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Which protein synthesis inhibitors are bacteriocidal?
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AGs, streptogramins (in combo)
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Which ABX would give a pt brown piss?
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Nitrofurantoin
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