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11 Cards in this Set
- Front
- Back
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Nephrotoxic drugs
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NSAIDS
Diuretics Aminoglucosides Cyclosporin Gold (Nephrotoxic Drugs Are Commonly Given) |
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Acetazolamide
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Carbonic anhydrase inhibitor causing NaHCO3 diuresis and reduction in total HCO3 stores
Tx: glaucoma, urinary alkalinization, metabolic alkalosis, altitude sickness ae: hyperchloremic metabolic acidosis, neuropathy, NH3 toxicity, sulfa allergy (ACIDazolamide causes ACIDosis) |
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Furosemide
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Sulfonamide loop diuretic
Inhibits cotransport system (Na, K, 2Cl) ot TAL Tx: edemedous states AE: ototoxicity, hypokalemia, dehydration, allergy, nephritis (interstitial), gout (OH DANG) |
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Ethacrynic acid
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Not a sulfonamide, same action as furosemide
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Hydrochlorothiazide
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Inhibits NaCl reabsorption in early distal tubule, reducing diluting capacity of the nephron. Decreased Ca excretion.
Tx: HTN, CHF, idiopathic hypercalciuria, nephrogenic diabetes insipidus AE: hypokalemic metabolic alkalosis, hyponatremia, hyperglycemia, hyperlipidemia, hyperuricemia, and hypercalcemia, sulfa allergy |
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Spironolactone
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K sparing diuretic
Competative aldosterone receptor antagonist in the cortical collecting tubule Tx: hyperaldosteronism, K depletion, CHF AE: hyperkalemia (leading to arrhythmias), gynecomastia, antiandrogen effects |
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Triamterene
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Block Na channels in the cortical collecting tubule
Tx: hyperaldosteronism, K depletion, CHF AE: hyperkalemia |
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Amiloride
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Block Na channels in the cortical collecting tubule
Tx: hyperaldosteronism, K depletion, CHF AE: hyperkalemia |
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Captopril, enalapril, lisinopril
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ACE inhibitors, renin release is increased due to loss of feedback inhibition
Tx: HTN, CHF, diabetic renal disease AE: cough, angioedemia, proteinuria, taste changes, hypOtension, pregnancy problems (fetal renal damage), rash, increased renin, lower angiotensin II (CAPTOPRIL) avoid with bilateral renal artery stenosis |
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Losartan
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angiotensin II receptor antagonist, doesn't cause cough or angioedema
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Drugs that cause gynecomastia
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spirololactone, digitalis, cimetidine, alcohol, ketoconazole
(Some Drugs Create Awesome Knockers) |
