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36 Cards in this Set
- Front
- Back
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Membranous Nephropathy (Nephrotic)
*Sup-epi deposits, spike and dome |
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Membranous Nephropathy (Nephrotic)
*thickened BM and capillary
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Membranous Nephropathy (Nephrotic)
*silver stain w/ spike and dome |
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Advanced Membranous Nephropathy (Nephrotic)
*Thickened capillary eventually closes off lumen to decrease GFR |
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Normal Glomerulus |
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B = Minimal Change Disease (nephrotic) with foot process effacement
A is normal foot process for comparison |
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Focal Segmental Glomerulosclerosis (nephrotic) |
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+ anti-dsDNA test global erythematous rash |
SLE Class V - Membranous Nephropathy (nephrotic) |
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+ anti-dsDNA test global erythematous rash |
SLE Class V - Membranous Nephropathy (nephrotic) |
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congo red stain |
Amyloidosis(nephrotic)
*amyloid deposits in mesangium |
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under polarized light |
Amyloidosis (nephrotic)
*"Apple Green Birefringence" |
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Diabetic Nephropathy (nephrotic)
*thickened BM of capillary |
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Diabetic Nephropathy (nephrotic)
*thickened BM of capillary |
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Diabetic Nephropathy (nephrotic)
*diffuse glomerulosclerosis and thickened/hyalinzed arterioles |
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Diabetic Nephropathy (nephrotic)
*diffuse glomerulosclerosis [top] *Nodular glomerulosclerosis ie Kimmelstein-Wilson nodules [bottom] |
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Diabetic Nephropathy (nephrotic)
*Thickened/hyalinized arteriole [left] *Mesangial expansion [middle] * Nodular glomerulosclerosis [right] |
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End-Stage Diabetic Nephropathy (nephrotic)
*Capillaries and Mesangium so thick that lumens are occluded resulting in decreased GFR * Thickened tubular BM [right] |
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Pt has hematuria and RBC casts |
Poststrep. Glomerulonephritis (Nephritic)
*hypercellular glomerulus full of Neutro's |
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Pt has hematuria and RBC casts |
Poststrep. Glomerulonephritis (Nephritic)
*hypercellular glomerulus full of Neutro's |
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Pt has hematuria and RBC casts |
Poststrep. Glomerulonephritis (Nephritic)
*Granular IF + for IgG, IgM, C3 ("lumpy-bumpy") |
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IF was granular and + for IgG, IgM, C3 |
Poststrep. Glomerulonephritis (Nephritic)
*Sup-epithelial deposits |
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Rapidly Progressive Glomerulonephritis (Nephritc)
*Crescents of fibrin thrombi in capillaries & Bowman's space and macrophages |
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taken from lung from pt w/ hemoptysis, hematuria, and RBC casts |
Goodpasture Syndrome (RPGN - Nephritic)
*Anti-BM antibody (against alpha3 of collagen IV) cross-reacts with glomerular and alveolar BM
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+ c-ANCA Pt has chronic sinusitis and hemoptysis |
Wegner's Granulomatosis (Pauci-Immune RPGN - Nephritic)
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IF + for IgA |
IgA Nephropathy (aka "berger disease") (nephritic - episodic hematuria)
* post mucosal infection * LM variable with mesangial proliferation and +/- sclerosis
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Pt also has hearing loss and occular disturbances |
Alport Syndrome (Nephritic)
*Inherited defect in alpha5 of collagen IV |
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Membranoproliferative Glomerulonephritis (Nephrotic & Nephritis)
* BM and Mesangial proliferation that splits BM ("tram-tracking") |
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Membranoproliferative Glomerulonephritis (Nephrotic & Nephritis)
*arrow show "tram-tracking" |
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Membranoproliferative Glomerulonephritis (Nephrotic & Nephritis)
*arrow show "tram-tracking" |
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Membranoproliferative Glomerulonephritis Type 2 (Nephrotic & Nephritis)
*Intramembranous deposits |
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+ anti-dsDNA test global erythematous rash < 50% glomeruli effected |
Focal Proliferative Glomerulonephritis - Type 3 Lupus Nephritis (Nephrotic & Nephritic)
*mesangial and endothelial proliferation with thrombi in capillaries * sub-endo deposits, + for IgG |
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+ anti-dsDNA test global erythematous rash all glomeruli effected |
Diffuse Proliferative Glomerulonephritis - Type 4 Lupus Nephritis (Nephrotic & Nephritic)
*mesangial and endothelial proliferation with thrombi in capillaries |
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+ anti-dsDNA test global erythematous rash all glomeruli effected |
Diffuse Proliferative Glomerulonephritis - Type 4 Lupus Nephritis (Nephrotic & Nephritic)
*massive sub-endothelial deposits create "wire loops" around capillaries |
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+ anti-dsDNA test global erythematous rash all glomeruli effected |
Diffuse Proliferative Glomerulonephritis - Type 4 Lupus Nephritis (Nephrotic & Nephritic)
*Sub-endothelial granular IgG deposits |
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+ anti-dsDNA test global erythematous rash all glomeruli effected |
Diffuse Proliferative Glomerulonephritis - Type 4 Lupus Nephritis (Nephrotic & Nephritic)
*massive Sub-endothelial deposits |
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+ anti-dsDNA test global erythematous rash all glomeruli effected |
Diffuse Proliferative Glomerulonephritis - Type 4 Lupus Nephritis (Nephrotic & Nephritic)
*massive Sub-endothelial deposits |
