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8 Cards in this Set
- Front
- Back
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Difference between Wegner's Granulomatosis, Microscopic PAN
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Wegner's: P-ANCA, PAN: C-ANCA
Wegner's: Presents with otitis media, sinusitis, keratoconjunctivitis, pneumonia |
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Activity Indicators of SLE
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Globerular Cell Proliferation
Leukocyte Exudation Cellular Crescents Fibrinoid Necrosis Hyaline Deposits Hyalin thrombi Interstitial Mononuclear Inflammatory Infiltrate Wire Loops |
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Criteria for Diagnosis of SLE
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Malar Rash
Discoid Rash Photosensitivity Oral Ulcers Arthritis Serositis Renal Disorders Neurologic Disorders Hematologic Disorders Immunologic Disorders ANA |
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Glomerular Changes in DM
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Basement Membrane Thickening
Diffuse Glomerulosclerosis- increased Mesangial Matrix Nodular Glomerulosclerosis (Kilmmelstiel-Wilson): increased mes. matrix with nodular appearance Diffuse linear IgG staining along capillary loops, tubular BM and Bowman's Capsule |
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Difference between Microscopic and Macroscopic Polyarteritis Nodosa
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Classic (Macroscopic)- more commoen in men, during 5th-6th decade, medium arteries like coronaries, spares lung, lesion of different ages in same organ
Hypersensitivity Angitis (Microscopic Polyarteritis): Hx of allergy common. All lesions of same age. Involves Lung |
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Amyloidosis Classification Themes
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Primary- Immunocyte Dyscrasias
Secondary- chronic inflammation: rheumatoid arthritis, ankylosing spondylitis, IBS, TB, chronic osteomyelitis Hereditary- AA fibril, Familial Mediterranean Fever AL- immunocyte dyscrasias: heart, tongue, GI, nerves, skin AA- Serum Amyloid A (SAA)- a HDL, synthesized in liver, found in chronic inflammatory conditions- involves liver, kidney, adrenal, spleen |
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Renal Manifestations of DM
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Glomerular Changes
Arteriosclerosis Fibrous Crescents Interstitial Fibrosis |
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Alport Syndrome: Histo, IF, ultrastructural features
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Defect of Type IV Collagen, alpha 5 chain
Histo- Glomerular Proliferation/Sclerosis, Increased Mesangial Matrix, fetal glomeruli, Foam Cells, Tubular Atrophy, Interstitial Fibrosis IF- Negative EM- Attenuation, thickening, splitting, lamellation of BM |
