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12 Cards in this Set

  • Front
  • Back
change na conc reflect disturbed ___ homeostasis
H2O
In PT, Ang II and NE tweek ? on apical and ? on basolateral to promote na reabs
Na/H on apical (lumenal side)
Na/K ATPase basolateral side
In Cortical C.D. ____ inc. Na reabs

ENaC on ? side and Na/K ATPase on ? side
Aldosterone

work ENaC apical and Na/K ATPase on basolateral
What else ADH do besides inc. aquaporin ch. in CD
1. inc Na reabs in th. asc. limb and CCD
2. Inc. urea transport in IMCD (TO HELP MAINTAIN CONC. Gradient in INNER MEDULLA w/o conc. ADH wouldn't be effective!
dec. osmolality, dec. vol.(hypotens) and inc. Ang all cause INC. in ?
ADH aka vasopressin and Thirst
Pl Na<136, INC. h2O, inc. na, dec. plasma osm, Una<20mm/L, Uosm: high to isoosmotic
Hypervol. Hyponatremia
d/t EDEMA ish (3rd spacin: CHF, cirrhosis w/ ascites, adv. renal fail, nephrotic syndrome)

hyponat want to stop ADH BUT loss blood vol. therefore high ADH. urine conc. varies d/t dec art. blood vol (want inc. ADH) but hyponatremia (want dec. ADH)
Inc. cap hydraulic P, dec. cap oncotic P, dec. cap permeability, lymph obstruction all-->
Edema, inc. interstitial Oncotic P inc.
True vol depletion, dec h2o, DEC. Na, dec. plasma osmol, Uosm low to high

extrarenal if?
renal if?
Hypovol hyponat
extrarenal=Una<20mm/L
renal=Una>20mm/L
extrarenal=GI loss, xs sweat, burns, 3rdspacin
renal= diuretics, mineralocorticoid def., ketonuria, bicarbonuria, salt-wastin neuropathy
INC INC Una >40mm/L dec. plasma osmolality, Uosm high

what if Uosm low?
Normovolemic hyponatremia: Uosm high= SIADH or ish that mimics (hypothyroidism, adrenal glucocorticoid defic)

Uosm low= toast tea, beer potomania, primary polydipsia
inc H2o INC. Na, Inc Plosm
hypervol hypernatremia
ex=hypertonic salin xs, NaHCO3 sol'n
Diabetes insipidus causes __volemic ___natremia
normovolemic hypernatremia, too lil adh! Febrile pt.'s, net H2O loss w/ no change body Na therefore
Inc Plosm, dec. Uosm
Uosm High, DEC. H2o dec. Na INC. Plsosm!

can be extrarenal or renal
hypovolemic hypernatremia

Renal causes- Thiazide, osmotic diuretic(urea,glucose, mannitol, glycol)

Extrarenal= GI loss(diarrhea,vomit), xs sweat, burns