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4 Cards in this Set
- Front
- Back
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describe the molecular pathway leading to BPH. what drugs can stop this?
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testosterone (via 5 a reductase)-> DHT -> binds nuclear androgen receptor 6. this leads to growth of both stromal and glandular cells.
nuclear androgen receptor 6 is stimulated by estradiol, which expressed more in elderly -potential drugs: inhibitors of 5alpha reductase; alpha1a antagonists |
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what type of cancers occur in prostate? how do they spread? to where?
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adenocarcinomas, spread via lymphatics, metastasize to bone
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cancer of prostate - describe the grading and staging scales
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grade: Gleason system, 2-10. 10 is worst = least differentiated
stage: A-D. A is not palpable. B is palpable. C has extended through the capsule. D is metastasized |
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prostate tumor Dx markers:
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Prostate Specific Antigen (PSA) - higher in both BPH and cancer. complexed form is related to cancer, free form is related to BPH
-Prostatic Acid Phosphatase - indicates bone metastasis |
