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20 Cards in this Set

  • Front
  • Back
what are the 3 primitive forms of the kidney
what happens to the pronephros
it completely regresses
what happens to the mesonephros
completely regresses, except for the wolffian duct
what happens to the metanephros
becomes the adult kidney
what are the 2 components of the metanephros
ureteric bud
metanephric mesoderm
what does the ureteric bud become in the adult
minor and major calyces
renal pelvis
collecting ducts
what does the metanephric mesoderm become in the adult
proximal tubule
loop of henle
distal tubule
connecting tubule (connects distal tubule to collecting duct)
where is the fetal metanephros located?
where is the adult kidney loctated?

what accounts for the change in location of the kidneys?
sacral region


disproportionate growht of the embryo caudal to the metanephros; during this time the kidneys also rotate medially by 90 degrees
where does the urinary bladder develop?
upper end of hte UG sinus, which is continuous with the allantois
what does the allantois become
it degenerates and becomes the median umbilical ligament (aka urachus)
how is the trigone of the bladder formed?
it gets incorportatd into the mesonephric duct into posterior wall of UG sinus
describe the formation of the adrenal cortex
forms from 2 episodes of mesoderm proliferation (1st forms fetal cortex which regresses by 2nd postnatal month, 2nd forms adult cortex)

ZG and ZF are present at birth, ZR develops by 3 years of age
describe formation of the adrenal medulla
neural crest cells aggregate at medial aspect of fetal cortex and eventaully become surrounded by fetal cortex
the neural crest cells then differentiate into chromaffin cells
potter's syndrome
bilateral renal agenesis --> oligohydramnios --> compression of fetus
incompatible with life unless htere is a kidney donor
-> pulmonary hypoplasia b/c amniotic fluid is needed for alveolar development
horseshoe kidney
inferior poles of both kidneys fuse
during ascent, it gets trapped behind the IMA
urachal fistula
allantois persists --> direct connection between urinary bladder and umbilicus
urine drains from umbilicus
histology of wilms' tumor
most common primary renal tumor of childhood
contains 3 different histologies (stroma, mblastemal area of tightly packed embryonic cells, tubular area)
polycystic kidney dz
loop of Henle dilates --> cysts that compromise kidney fxn

also have cysts in liver, pancreas, lung

primitive neuroblasts of neural crest origin, occurring in children
in extra-adrenal sites 60% of time and n adrenal gland 40% of time

arranged in Homer-Wright pseudorosettes
lab values of neuroblastoma
increased VMA and metanephrine levels
mets widely!