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48 Cards in this Set

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histopathologic changes of glomerulonephritis
cellular proliferation (epithelia crescents)
leukocytic infiltration
membranous change
hyalinization
thrombosis, necrosis, and dep of fibrin
non immune mechanism of glomerular disease
hereditary (ch 16 APKD)
metabolic (increased glycosylation of GBM, diabetes
hyperperfusion
cahnge of charge of glomerular filter (usually ned)
Non inflammatory glomerular disease
minimal change
focal scerosing GN
membranous GN
Diabetes mellitis
Amyloidosis
Inflammatory glomerular disease
acute proliferative GN
rapidly pregressive GN
Membranoproliferative GN
IgA nephropathy
Chronic GN
SLE
HSP
Cryoglobuinemic GN
minimal change
nephrotic
non inflammatory
FSGN
nephrotic
non inflammatory
membranous
nephrotic
non inflammatory
MPGN
nephrotic or nephritic
inflammatory
SLE GN
nephrotic
inflammatory
Diabetic GN
nephrotic
non inflammatory
amyloidosis
nephrotic
non inflammatory
APGN
nephritic
imflammatory
IgA nephropathy
nephritic
inflammatory
Cryoglubulinemic GN
nephritic
inflammatory
HSP GN
nephritic
inflammatory
vasculitis Gn
nephritic
acute renal failure
RPGN
Acute tubular necrosis
interstitial nephritis
RPGN GN
acute renal failure
Acute tubular necrosis
Acute renal failure
interstitial nephritis
Acute renal failure
Minimal Change Disease
nephrotic, edema, proteinuria
mostly children, responsive to steroids
nml histology
negative fluorescence
diffuse effacement or fusion of epith foot process on EM
most pt resp on steroid, if not probably FSGN
Focal Segmental Glomerular Sclerosis
nephrotic, microscopic hematuria, all pt need transplant
no response to steroids
hist: segmental glomerular fibrosis within scar and hyaline deposit and foam cell
IF: igM and C3
US: looks like MCD in uninvolved, variable foot proccess effacement, vaculoization, no immune deposits, cell debris
HIV nephropathy
like FSGN
Membranous Nephropathy
in situ immune complex dep
nephrotic sydrome, peak at 4th, 5th decade, rare in children, females,
hist: early nrmal, late diffuse capillary wall thickening, spikes of GBM bw immune dep
IF: most useful, granular IgG and C3 along GBM,
US: electron dense dep along GBM
responds to withdrawel of drugs or treatment of infxn causing disease, steroid
causes of secondary MGN
drugs gold penicillin
infxn hep b, syph, malaria
renal vein thrombosis,
lung cancer, colon
SLE
Diabetic GN
irreversible glycosylation of lysine
proteinuria
nodular diabetic glomerusclerosis Kimmelstiel Wilson Disease (microaneurysms in retina)
Hist: acellular nodule (KW), collagen
IF: nonspecific linear GBM IgG
US: diffuse thickening of GBM
diabetes can cause what renal problems
Diabetic GN
diabetic vascular disease of kidney
pyelonephritis
papillary necrosis
Amyloidosis
deposition of diverse extracellular proteins
insoluble, CONGO RED STAIN
Hist: hypocellular glomeruli, expansion of mesangium, accumulation of amorphous acellular mat
IF: ~
US: amyloid fibrils, tangled appearance
AL amyloid
secondary to monoclonal gammopathies, LC deposition
AA amyloid
associated chronic inflammatory disease (RA, chronic infxn, tuberculosis, ostemyelitis, neoplasms, hodgekins), acute phase proteins, amyloid fibrils,
nephritic syndrom
inflamed glomeruli
GFR reduced
hypervolumic, HTN, edema
red cell casts
microscopid detection of RBC casts in fresh urine sample
nephritic syndrom
Acute proliferative GN
post infections GABHS
Hist: hypercellular glomeruli, PMN, hemorrhagic necrosis
endothelial cell in loop, inflammatory cell in vasc lumen
IF: granular discrete deposits of IGg
US: electron dense deposits on epithelial side of basement membrane, endothelial cell swelling
Types of RPGN
RPGN with anti GBM ab
RPGN with Immune complexes
Pauci immune RPGN
P-ANCA
peri nuclear staining with pauci immune RPGN
C-ANCA Ab
cytoplasmic staining in patients with wegeners granulomatosis
Pauci immune RPGN
no GBM ab or immune complex
could be microangiitis, wegeners granulomatous vasculitis, frequently have positive ANCA
infiltration of parietal epithelial cells of bowmans capsule
RPGN
Crescents that contain Fibrin with MO infiltration
RPGN
RPGN treatment
cyclophosphamidr
Membranoproliferative GN
selective depletion of serum complement compnents in C3, 5, 6, 7
INTERPOSITION of mesangial cells
MPGN
Hematuria is the rule
OR
A woman presents with hematuria only
IgA nephropathy
thin gomerular basement membrane disease
Double contour Basement Membrane
MPGN
IgA Nephropathy
hist: mesangial enlargement, dark mesangial deposits
Henoch Schoenlein Allergiv Purpura
focal GN, hematureia, PURPURA, ARTHRITIS, ABDOMINAL PAIN
Major Association with hep C infxn and palpable purpura
essential mixed cryoglobulinemic GN
Wire Loop
Hematoxylin body
finger print pattern on EM
common histopath finding of type IV SLE GN