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21 Cards in this Set
- Front
- Back
Formation of the nephrogenic cord
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Lateral folding --> separation of intermediate mesoderm --> ridge on posterior coelom
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Mesonephros components
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Mesonephric duct and mesonephric tubules
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Mesonephric duct development
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Solid cord (thoracocolumnar region) extends caudally --> canalizes --> fuses with cloaca
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Mesonephric tubule development
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Grow out from mesonephric duct and associate with capillaries (cranially --> caudally)
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Fate of mesonephric duct (MALES)
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ejaculatory duct, epididymis, vas deferens, seminal vesicles
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Fate of mesonephric ducts (FEMALE)
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Nothing
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Fate of mesonephric tubules (MALE)
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efferent ductules
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Fate of mesonephric tubules (FEMALE)
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Nothing
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Ureteric bud/metanephrogenic mesenchyme inductive signaling
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MM --> Ureteric bud --> branch
Ureteric bud --> MM --> differentiate |
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Ureteric bud (metanephric diverticulum) development
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Outgrowth from distal mesonephric duct (where it enters the cloaca)
Ampulla = swelling at distal end |
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Metanephric nephron development
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Branched ampulla signals to MM --> MM condense around ampulla --> MM forms vesicle --> vesicle fuses with ampulla --> elongation into S-shape --> vascular precursors invade tubule
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Derivatives of S-shaped tubule
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Proximal --> distal tubule, loop of Henle
Middle --> proximal tubule Distal --> Bowman's capsule |
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Derivatives of ureteric bud
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3rd-6th branches --> ca;yces, renal pelvis, ureters
>6th branches --> collecting ducts |
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Ampulla
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Swelling of distal ureteric bud; provides inductive signals to metanephrogenic mesenchyme
Disappears around week 32 --> no new nephrons |
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Cloaca
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End of hindgut; common outlet for GI and urinary tracts
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Cloacal division
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Urorectal septum expands caudally to fuse with the cloacal membrane
UG sinus is ventral Anorectal canal is dorsal |
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Subdivisions of UG sinus
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Primary UG sinus --> vesicle part (cranial), definitive UG sinus (caudal); divided by entrance of MESONEPHRIC DUCTS
Definitive UG sinus --> pelvic, phallac |
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Bladder development
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IN MALE: Mesonephric ducts move caudally to primitive urethra
Posterior bladder thickens (trigone of urinary bladder) |
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Urethra development
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Forms from the caudal part of vesicle part of UG sinus
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Urethra derivatives (MALE)
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Pelvic --> epithelium of distal prostatic and membranous urethra
Phallic --> epithelium of penile urethra |
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Urethra derivatives (FEMALE)
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Pelvic --> epithelium of lower half of vagina
Phallic -->epithelium of vestibule |