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21 Cards in this Set

  • Front
  • Back
Formation of the nephrogenic cord
Lateral folding --> separation of intermediate mesoderm --> ridge on posterior coelom
Mesonephros components
Mesonephric duct and mesonephric tubules
Mesonephric duct development
Solid cord (thoracocolumnar region) extends caudally --> canalizes --> fuses with cloaca
Mesonephric tubule development
Grow out from mesonephric duct and associate with capillaries (cranially --> caudally)
Fate of mesonephric duct (MALES)
ejaculatory duct, epididymis, vas deferens, seminal vesicles
Fate of mesonephric ducts (FEMALE)
Nothing
Fate of mesonephric tubules (MALE)
efferent ductules
Fate of mesonephric tubules (FEMALE)
Nothing
Ureteric bud/metanephrogenic mesenchyme inductive signaling
MM --> Ureteric bud --> branch

Ureteric bud --> MM --> differentiate
Ureteric bud (metanephric diverticulum) development
Outgrowth from distal mesonephric duct (where it enters the cloaca)

Ampulla = swelling at distal end
Metanephric nephron development
Branched ampulla signals to MM --> MM condense around ampulla --> MM forms vesicle --> vesicle fuses with ampulla --> elongation into S-shape --> vascular precursors invade tubule
Derivatives of S-shaped tubule
Proximal --> distal tubule, loop of Henle

Middle --> proximal tubule

Distal --> Bowman's capsule
Derivatives of ureteric bud
3rd-6th branches --> ca;yces, renal pelvis, ureters

>6th branches --> collecting ducts
Ampulla
Swelling of distal ureteric bud; provides inductive signals to metanephrogenic mesenchyme

Disappears around week 32 --> no new nephrons
Cloaca
End of hindgut; common outlet for GI and urinary tracts
Cloacal division
Urorectal septum expands caudally to fuse with the cloacal membrane

UG sinus is ventral
Anorectal canal is dorsal
Subdivisions of UG sinus
Primary UG sinus --> vesicle part (cranial), definitive UG sinus (caudal); divided by entrance of MESONEPHRIC DUCTS

Definitive UG sinus --> pelvic, phallac
Bladder development
IN MALE: Mesonephric ducts move caudally to primitive urethra

Posterior bladder thickens (trigone of urinary bladder)
Urethra development
Forms from the caudal part of vesicle part of UG sinus
Urethra derivatives (MALE)
Pelvic --> epithelium of distal prostatic and membranous urethra

Phallic --> epithelium of penile urethra
Urethra derivatives (FEMALE)
Pelvic --> epithelium of lower half of vagina

Phallic -->epithelium of vestibule