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18 Cards in this Set

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What is Renal Clearance?
not just the amount of X measured in urine;
the amount of PLASMA from which X is removed. Per minute.
what is the equation for renal clearance?
. . . [S]x V
C = -------
. . . [S]*
[S] is conc of X in urine.
V is volume of urine/time
[S]* is conc of X in plasma.
What 3 things do you have to know in order to calculate clearance?
1. Whether X is filtered
2. Whether X is reabsorbed
3. Whether X is secreted.
What does inulin and creatinine clearance tell?
glomerular filtration rate
-> creat FR is approximate.
what is inulin?
not found in the body normally, but administered IV to measure GFR.
What does inulin do?
-filt
-secr
-reab
Filtered
Not secreted
Not reabsorbed
Therefore, Inulin Clearance = glomerular filtration rate.
What does creatinine do?
-filt
-secr
-reab
Is filtered
Is secreted alittle bit
Not reabsorbed
Therefore, Creat clnc = GFR approximately.
if creatinine is secreted a little bit, is its clearance greater or less than GFR?
Greater than GFR.
what is PAH and what does it tell?
Para-aminohippurate

-Its value tells RPF Renal plasma flow
What does PAH do?
-filt
-secr
-reab
Filtered
Completely secreted
None reabsorbed
Therefore, it's all taken out of the body, and tells how much plasma is going through the kidney.
What is Renal Blood Flow equal to in terms of CO?
20-25% of Cardiac Output
What is typical CO?
5 L/min
what is RBF equal to in terms of RPF?
RBF=RPF/1-Hct
What does Glucose do?
-filt
-secr
-reab
Filtered
None secreted
All reabsorbed - therefore, NO glucose is normally cleared.
When WOULD some glucose get cleared, and why?
under abnormal conditions - Diabetes mellitus.
Because membrane transporters have a maximum, and the filtered load exceeds it.
What is "Filtered Load"?
Filt. Load = PX x GFR

PX = plasma conc of X
What is Tubular Transport Maximum and where is it important?
the maximum amount of X that can be reabsorbed; when glucose filtered load is increased, it exceeds this max and gets excreted.
What is the effect of glucosuria on urine concentration?
Causes water to be secreted, urine volume increases, and the patient is thirsty.